Abstracts Archive - Page 1445 of 1683 - ATC Abstracts

2015 American Transplant Congress
Defining and Directing T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
M. Fryer, G. Furtmùller, B. Oh, S. Reddy, K. Sarhane, G. Raimondi, G. Brandacher, D. Cooney.
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Purpose: Wider utilization of VCA is hampered by the need for long-term immunosuppression. Barriers to more targeted immunosuppression in VCA include (1) limited knowledge of…
2015 American Transplant Congress
Both Preformed and De Novo Cw Donor Specific Antibodies Are Clinically Significant in Renal Transplantation
A. Gueret-Wardle, M. Willicombe, V. Dibbur, P. Brookes, A. McLean, D. Taube.
Imperial College Kidney and Transplant Centre, Imperial College NHS, London, United Kingdom.
Preformed [PF] and de novo [DN] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody…
2015 American Transplant Congress
Somatostatin (Eumedica®) Infusion Allows Modulating Graft Flows and Gradients in Liver Transplantation. Results of a Randomized, Double Blind, Placebo Controlled Trial
R. Troisi,¹ A. Croo,¹ E. Codarin,³ E. De Wolf,¹ J. Van Limmen,⁴ G. Antoniali,³ B. Heyse,⁴ L. De Baerdemaeker,⁴ I. Colle,⁵ G. Tell,³ M. Sainz-Barriga.^1,2
¹General Hepatobiliary Surgery Liver Transplantation Service, Ghent University Hospital Medical School, Ghent, Belgium; ²Digestive Surgery & Liver Transplantation, University of Tours, Tours, France; ³Medical & Biological Sciences, University of Udine, Udine, Italy; ⁴Anesthesiology, Ghent University Hospital Medical School, Ghent, Belgium; ⁵Gastroenterology, Ghent University Hospital Medical School, Ghent, Belgium.
Background: Somatostatin (SST) infusion decrease portal pressure in acute variceal bleeding in cirrhotic patients. Despite liver transplantation (LTx), recipients with portal hypertension (PHT) display different…
2015 American Transplant Congress
Liver Fabrication Using Whole Organ Scaffold for Transplantable Graft in Large Animal
K. Inomata,¹ H. Yagi,¹ K. Tazima,¹ K. Sugiyama,¹ M. Hieda,¹ T. Hibi,¹ Y. Abe,¹ M. Kitago,¹ M. Shinoda,¹ O. Itano,¹ T. Akaike,² Y. Kitagawa.¹
¹Surgery, Keio University, Tokyo, Japan; ²Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo, Japan.
Background and aims: Orthotopic liver transplantation is only effective treatment for end-stage liver disease, however it is limited by shortage of donor livers. Therefore, novel…
2015 American Transplant Congress
Bladder Drainage of Pancreas Transplants Alone: Friend or Foe?
M. Bellini,¹ G. Spoletini,² S. Reddy,¹ J. Gilbert,¹ I. Quiroga,¹ R. Ploeg,¹ E. Sharples,³ S. Sinha,¹ A. Vaidya,¹ P. Friend.¹
¹Nuffield Department of Surgery, Oxford University Hospital NHS Trust, Oxford, United Kingdom; ²Department of Hepatobiliary and Transplant Surgery, Royal Free London NHS Trust, London, United Kingdom; ³Nuffield Department of Medicine, Oxford University Hospital NHS Trust, Oxford, United Kingdom.
Introduction: Immunological monitoring of Pancreas Transplants Alone (PTA) remains a challenge and bladder drainage is thought to facilitate early detection of rejection but may lead…
2015 American Transplant Congress
Moderate Rejection Episode of Face Transplant After mTOR Conversion to Preserve Renal Function
R. Barth,¹ B. Bojovic,¹ J. Woodall,¹ M. Uluer,¹ C. Drachenberg,¹ C. Shaffer,¹ N. Kelly,¹ E. Rodriguez,² S. Bartlett.¹
¹University of Maryland School of Medicine, Baltimore; ²New York Medical University, New York City.
Face and hand vascularized composite allografts (VCA) have demonstrated durable graft survivals with conventional immunosuppression but with the appearance of renal dysfunction. Management strategies that…
2015 American Transplant Congress
Inhibition of mTOR Modulates SLPI Expression: A Potential Role in Kidney Transplant Patients
N. Ambrosi,¹ A. Dotta,² C. Pizarro,² D. Guerrieri,¹ A. Gonzalez,² C. Leiva,² L. Leon,² J. Mendiberri,³ M. Rial,² C. Incardona,⁴ E. Chuluyan,¹ D. Casadei.²
¹CEFYBO, UBA, Buenos Aires, Argentina; ²Fundacion 3er Milenio, INBA, Buenos Aires, Argentina; ³UNICEN, Olavarria, Argentina; ⁴Fundación GADOR, Buenos Aires, Argentina.
Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor secreted by inflammatory and epithelial cells. It functions as an endogenous immunomodulatory, with antiinflammatory and…
2015 American Transplant Congress
Mononuclear Cell Infiltrates Characterization in Scar Tissue from a Bilateral Forearm Transplant Patient: Findings to Think
J. Furuzawa-Carballeda,¹ M. Iglesias,² J. Alberu,³ A. Gamboa,⁴ P. Butrón,² M. Morán-Romero,² Y. Esquivel.¹
¹Immunology, INCMNSZ, Mexico City, Mexico; ²Plastic Surgery, INCMNSZ, Mexico, Mexico; ³Transplants, INCMNSZ, Mexico, Mexico; ⁴Pathology, INCMNSZ, Mexico City, Mexico.
Herein we report the cell infiltrating pattern in scar tissue resected at the junction of the VCA and the tissue corresponding to the recipient arm,…
2015 American Transplant Congress
Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs
A. Salama,^1,2 S. Conchon,¹ A. Perota,³ B. Martinet,¹ J.-P. Judor,¹ G. Evanno,¹ S. Le-Bas Bernardet,¹ L. Le Berre,¹ J. Hervouet,¹ D. Minault,¹ J.-P. Concordet,⁴ E. Dugast,¹ B. Vanhove,¹ J. Abadie,⁵ N. Gaide,⁵ I. Lagutina,³ R. Duchi,³ G. Lazzari,³ D. Sachs,⁶ O. Gauthier,⁷ S. Brouard,¹ E. Cozzi,⁸ G. Blancho,¹ H. Perreault,⁹ J.-M. Bach,¹⁰ C. Galli,^3,11 J.-P. Soulillou.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; ⁴INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; ⁵AMaROC, ONIRIS, Nantes, France; ⁶Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; ⁷Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; ⁸Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; ⁹Chemistry Department, University of Manitoba, Winnipeg, Canada; ¹⁰IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ¹¹Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
2015 American Transplant Congress
Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact
E. Montanari,¹ R. Mahou,^1,2 S. Passemard,² F. Noverraz,² P. Morel,¹ R. Meier,¹ D. Bosco,¹ J. Seebach,³ C. Wandrey,² S. Gerber,² C. Gonelle-Gispert,¹ L. Buhler.¹
¹Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; ²Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ³Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…