Abstracts Archive - Page 1426 of 1683 - ATC Abstracts

2015 American Transplant Congress
Impact of Machine Perfusion After Long Static Cold Storage On Delayed Graft Function Incidence and Duration and Time to Hospital Discharge
A. Matos,¹ M. Borrelli, Jr.,¹ L. Moura Requiao,¹ M. Nogueira, Jr.,¹ L. Pertusier,¹ G. Clarizia,¹ P. Ongaro,¹ S. Ximenes,¹ M. Durao, Jr.,^1,2 A. Pacheco-Silva.^1,2
¹Transplantation, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; ²Medicine/Nephrology, Escola Paulista de Medicina, UNIFESP, Sao Paulo, Brazil.
Our transplant center is not involved in organ harvesting and usually we receive a kidney for transplant with more then 20 hours of static cold…
2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…
2015 American Transplant Congress
Enhancing Kidney Function Following DCD Donation With Thrombolytic Therapy: A Preliminary Report of a Multicenter Prospective Quasi-Blinded Randomized Trial
K. Woodside,¹ D. Goldfarb,² J. Rabets,² E. Sanchez,¹ D. Lebovitz,³ J. Schulak,¹ J. Fung,² B. Eghtesad.²
¹Transplant Institute, University Hospitals Case Medical Center, Cleveland, OH; ²Transplant Center, Cleveland Clinic, Cleveland, OH; ³LIfebanc, Cleveland, OH.
Kidneys from donors following cardiac death (DCD) are at risk for inferior outcomes, possibly due to microthrombi and additional warm ischemia. We describe an organ…
2015 American Transplant Congress
Where Does It End? Outcome of the Rejected Kidney Offers for Potential Renal Transplant and Their Outcome. A Single Centre Experience
A. Ghazanfar, M. Al Azeez, M. Morsy, A. Bagul.
Renal Medicine and Transplant Surgery, St Georges Healthcare NHS Trust, London, United Kingdom.
Background: Worldwide there are no uniformly acceptable deceased donor selection criteria for renal transplantation. There are national and international guidelines available based on which most…
2015 American Transplant Congress
The Natural History of Kidney Graft Cortical Microcirculation Determined by Real-Time Contrast-Enhanced Sonography (RT-CES)
C. Jiménez,¹ M. López,¹ A. Ros,¹ A. Aguilar,¹ D. Menendez,¹ B. Rivas,¹ M. Santana,¹ R. Madero,² R. Selgas.¹
¹Nephrology, Hospital Univeritario La Paz, Madrid, Spain; ²Biostatistics, Hospital Univeritario La Paz, Madrid, Spain.
Decreasing kidney graft cortical microcirculation has been related to poor prognosis in kidney transplantation. Cortical capillary blood flow (CCBF) can be measured by real-time contrast-enhanced…
2015 American Transplant Congress
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
K. De Vusser,¹ K. Hochstenbach,² E. Winckelmans,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
¹Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; ³Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
2015 American Transplant Congress
Microvascular (MIA) and Interstitial (i) Inflammation Influence Late Death-Censored Graft Failure (DCGF) After Kidney Transplantation
R. Gaston,¹ A. Fieberg,² R. Leduc,² J. Connett,² F. Cosio,³ S. Gourishankar,⁴ J. Grande,³ L. Hunsicker,⁵ B. Kasiske,⁶ J. Cecka,⁷ A. Matas,² D. Rush.⁸
¹UAB, Birmingham; ²U Minnesota, Minneapolis; ³Mayo Clinic, Rochester; ⁴U Alberta, Edmonton, Canada; ⁵U Iowa, Iowa City; ⁶Hennepin County Med Ctr, Minneapolis; ⁷UCLA Immunogenetics, Los Angeles; ⁸U Manitoba, Winnipeg, Canada.
We and others have shown late DCGF is due to ongoing, most often immune, injury. Though there is general agreement that antibody-mediated injury is a…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
A Distinct Glomerular Complement Deposition Pattern in Transplant Glomerulopathy
P. Verghese, R. Reed, A. Matas, Y. Kim.
University of Minnesota, Minneapolis.
While many patients with transplant glomerulopathy (TG) have donor-specific antibodies, the lack of C4d deposition in the peritubular capillaries (ptc-C4d) in some cases has caused…
2015 American Transplant Congress
The Synergistic Effect of Class II HLA Epitope-Mismatch and Non-Adherence on Acute Rejection and Graft Survival
C. Wiebe,^1,2 T. Nevins,³ W. Robiner,^3,4 W. Thomas,⁵ A. Matas,⁶ P. Nickerson.^1,2,8
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Transplant Immunology, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pediatrics, University of Minnesota, Minneapolis, MN; ⁴Medicine, University of Minnesota, Minneapolis, MN; ⁵Public Health, University of Minnesota, Minneapolis, MN; ⁶Surgery, University of Minnesota, Minneapolis, MN; ⁷Immunology, University of Manitoba, Winnipeg, MB, Canada.
Predicting long-term outcomes in renal transplant recipients is essential to optimize medical therapy and determine the frequency of post-transplant pathologic and serologic monitoring. Non-adherence and…