ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Burden of Early Antibody-Mediated Rejection (AMR): Complications, Resource Utilization and Cost-Differential in Treatment of AMR

    R. Banga,1 C. Schinstock,1 A. Boscoe,4 M. Hathcock,3 W. Kremers,3 M. Stegall.2

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; 2Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; 3Division of Biostatistics, Mayo Clinic, Rochester, MN; 4Health Outcomes Research, Alexion Pharmaceuticals, Cheshire, CT.

    Early antibody-mediated rejection (AMR) is common in positive crossmatch kidney transplants (+XMKTx). The current study determined the complications, resource utilization and cost associated with early,…
  • 2015 American Transplant Congress

    Predictive Value of Regadenoson Scans After Heart Transplant

    J. Kawano, M. Kittleson, J. Patel, B. Azarbal, F. Liou, S. Siddiqui, D. Wong, D. Chang, D. Ramzy, L. Czer, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Cardiac allograft vasculopathy (CAV) is one of the major factors limiting long-term survival after heart transplantation. The use of annual coronary angiograms is an…
  • 2015 American Transplant Congress

    Modeling the Clinical and Cost-Effectiveness of Dobutamine Stress Echocardiography With Confirmatory Coronary Angiography for the Diagnosis of Pediatric Cardiac Allograft Vasculopathy

    D. Nandi, M. O'Connor, K. Lin, S. Paridon, C. Ravishankar, C. Mascio, R. Shaddy, J. Rossano.

    The Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, PA.

    Purpose: Cardiac allograft vasculopathy (CAV) is a leading cause of long-term mortality after pediatric heart transplantation. The gold standard of diagnosis is coronary angiography, an…
  • 2015 American Transplant Congress

    Determinants of Accelerated CAV in Heart Allografts: Major Independent Impact of Circulating DSA

    M. Bories, Varnous, Guillemain, Suberbielle, Jouven, Bruneval, Duong, Loupy.

    Paris Translational Research Center for organ Transplantation, Paris, France.

    BackgroundChronic allograft vasculopathy (CAV) is the leading cause of late failing heart allografts and is associated with mortality. The determinants of CAV integrating traditional cardiovascular…
  • 2015 American Transplant Congress

    Evaluating the Benefits of Everolimus on Cardiac Allograft Vasculopathy: Further Evidence from Results of Imputations for Missing IVUS Data from A2310 Study

    P. Lopez,1 G. Dong,2 Z. Wang.2

    1Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals, East Hanover, NJ; 3Novartis Pharmaceuticals, East Hanover, NJ.

    Purpose: A2310 IVUS study showed that everolimus (EVR) provides cardiac allograft vasculopathy (CAV) benefit compared to mycophenolate mofetil (MMF) by assessing the mean change in…
  • 2015 American Transplant Congress

    Incidence, Determinants and Outcome of Kidney Transplantation for End Stage Renal Disease After Heart Transplantation

    A. Grupper,1 A. Grupper,1 R. Daly,1 M. Hathcock,2 W. Kremers,2 F. Cosio,1 B. Edwards,1 S. Kushwaha.1

    1William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN; 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.

    Objectives: Progressive renal failure is a frequent complication following heart transplantation (HTx), is generally attributed to calcineurin inhibitor (CNI) based immunosuppression, and may result in…
  • 2015 American Transplant Congress

    Outcome of Renal Sparing Protocol in a Cross-Sectional Analysis After Heart Transplant

    J. Kobashigawa, M. Kittleson, P. Patel, F. Liou, S. Siddiqui, D. Chang, B. Azarbal, D. Ramzy, L. Czer, J. Patel.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Calcineurin inhibitors (CNIs) are the mainstay of immunotherapy after heart transplantation. Unfortunately CNIs are associated with renal dysfunction due to nephrotoxic side effects. The…
  • 2015 American Transplant Congress

    Acute Kidney Injury and Outcome After Cardiac Transplantation

    G. Fortrie,1 O. Manintveld,2 K. Caliskan,2 M. Betjes.1

    1Internal Medicine, Div. of Nephrology, Erasmus Medical Center, Rotterdam, Netherlands; 2Cardiology, Erasmus Medical Center, Rotterdam, Netherlands.

    Background:Chronic kidney disease (CKD) is a frequently seen complication after cardiac transplantation and is partly explained by the prolonged use of calcineurin inhibitors. However, few…
  • 2015 American Transplant Congress

    Does Prophylaxis Strategy Matter? CMV Reactivation in Moderate Risk (R+) Heart Transplant Recipients

    E. Liu, C. Doligalski.

    Pharmacy, Tampa General Hospital, Tampa, FL.

    Purpose: CMV is a significant complication in heart transplant recipients (HTR). Little evidence exists to guide prophylaxis in moderate risk (R+) patients.Methods: An IRB-approved review…
  • 2015 American Transplant Congress

    The Impact of Administrating Everolimus Before Cytomegalovirus Infection to Prevent CMV Recurrence in Heart Transplant Recipients

    M. Ishida, K. Toda, T. Nakamura, S. Miyagawa, Y. Yoshikawa, S. Fukushima, S. Saito, D. Yoshioka, K. Kubota, T. Ueno, T. Kuratani, Y. Sawa.

    Cardiovascular Surgery, Osaka University, Suita, Osaka, Japan.

    Purpose – Cytomegalovirus (CMV) infection is a major complication in heart transplant recipients. Recent trials indicate that the use of the mammalian target of rapamycin…
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