Abstracts Archive - Page 1411 of 1683 - ATC Abstracts

2015 American Transplant Congress
Financial Impact of an Advanced Liver Disease Service on a Tertiary Health System
A. Masoumi,¹ S. Hanish,² J. LaMattina,² C. Njoka,¹ W. Hutson,² D. Potosky,² R. Barth.²
¹University of Maryland Medical Center, Baltimore; ²University of Maryland School of Medicine, Baltimore.
Regional disparities in liver transplantation motivated revision of national organ-sharing policies towards critically ill patients. Liver transplantation of high MELD patients incorporates significant institutional commitment…
2015 American Transplant Congress
Evaluating Outcomes in Multi-Organ Liver Transplant Recipients
J. Snyder,¹ N. Salkowski,¹ D. Zaun,¹ B. Thompson,¹ J. Zeglin,¹ D. Schladt,¹ J. Lake,² W. Kim,³ A. Israni,¹ B. Kasiske.¹
¹SRTR, MMRF, Minneapolis, MN; ²University of MN, Minneapolis, MN; ³Stanford School of Medicine, Stanford, CA.
Historically, transplant (Tx) program evaluations performed by the Scientific Registry of Transplant Recipients (SRTR) in the US have included only single-organ Txs, except for simultaneous…
2015 American Transplant Congress
Factors Associated With Rehospitalization and High Cost Among Health Plan Members Receiving Kidney Transplants
E. Lee,¹ Y. Zhou,² B. Suehs,² B. Franks,¹ B. Kassman,¹ J. Spalding,¹ G. Thal.¹
¹Astellas Scientific and Medical Affairs, Northbrook, IL; ²Comprehensive Health Insights, Humana, Louisville, KY.
PurposeAims were to develop a claims-based algorithm to identify kidney transplant cases and to examine clinical and economic outcomes among health plan members undergoing kidney…
2015 American Transplant Congress
Attitudes and Beliefs About Organ Donation: Focus Group Study in Arabic-Speaking Communities in Australia
A. Ralph,^1,2 A. Alyami,^3,4 R. Allen,^3,4 K. Howard,¹ J. Craig,^1,2 S. Chadban,^3,4 M. Irving,^1,2 A. Tong.^1,2
¹Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia; ²Centre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia; ³Sydney Medical School, University of Sydney, Sydney, NSW, Australia; ⁴Transplantation Services, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Background: The demand for transplantable organs continues to outweigh supply across the globe, especially in the provision of deceased donor organs from ethnic minority populations.…
2015 American Transplant Congress
Primary and Secondary Vaccine Responses in a Non-Human Primate Model of Cardiac Allotransplantation
S. Dahi,¹ E. Kang,¹ T. Zhang,¹ B. Vanhove,² A. Azimzadeh,¹ R. Pierson III.¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; ²INSERM, Nantes, France.
Purpose: To compare the effect of calcineurin- versus costimulation-based immunosuppression on primary and secondary vaccine responses in non-human primate heart transplant recipients.Background: Antibody response following…
2015 American Transplant Congress
PI3Kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization
E. Kefalogianni,¹ M. Mounayar,² B. Smith,² J. Azzi,² L. Chabtini,² P. Fiorina,² M. Kraus,³ R. Briddell,⁴ W. Fodor,⁵ A. Herrlich,¹ R. Abdi.²
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Brigham and Women's and Children's Hospital, Harvard Medical School, Boston, MA; ³Viacord LLC, a PerkinElmer Company, Cambridge, MA; ⁴ViaCord Processing Lab, Viacord LLC, a PerkinElmer Company, Hebron, KY; ⁵The Cell Therapy Group, Madison, CT.
The immunomodulatory capacity of mesenchymal stem cells (MSC) is critical for their use in therapeutic applications. MSC response to specific inflammatory cues allows them to…
2015 American Transplant Congress
microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN
J. Yuan,¹ C. Benway,^1,2 J. Bagley,¹ J. Iacomini.^1,2
¹Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA; ²Sackler School of Biomedical Sciences Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, MA.
Purpose: A major complication associated with cyclosporine (CsA) treatment is nephrotoxicity. MicroRNAs (miRs) have been shown to play an important role in various pathological conditions,…
2015 American Transplant Congress
Anti-CD122 + Costimulation Blockade Prolongs Allograft Survival
D. Mathews,¹ L. Higginbotham,¹ Y. Dong,¹ C. Breeden,¹ C. Larsen,¹ J. Tso,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²JN Bioscience, Mountanview, CA.
Introduction: Effective T cell activation and effector function requires (1) cognate antigen recognition (2) appropriate costimulation and (3) successful cytokine signaling. Recently approved strategies to…
2015 American Transplant Congress
Emerging Application of Active Immune Targeted Delivery in Transplantation
M. Uehara,¹ A. Jamil,¹ M. McGrath,¹ Z. Solhjou,¹ N. Banouni,¹ S. Tullius,² C. Jianjun,³ R. Abdi.¹
¹Renal Division, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical Shcool, Boston, MA; ²Division of Transplant Surgery, Brigham and Women's Hospital, Boston, MA; ³Materials Science and Engineering, University of Illinois at Urbana-Champaign, Champaingn, IL.
Targeted nanodelivery has created enormous excitement as a transformative approach to deliver therapeutics to tissues of interest. In recent years, we have made significant progress…
2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
T. Ma, Y. Pei, R. Tao.
Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…