2015 American Transplant Congress
Rewarming of Cold Preserved Livers Decreases Graft Injury and Kupffer Cell Activation by Normothermic Extracorporeal Liver Perfusion (NELP)
Normothermic extracorporeal liver perfusion (NELP) is able to decrease ischemia reperfusion injury to the greatest degree when cold ischemic time is minimized. However, given the…2015 American Transplant Congress
Normothemic Machine Perfusion of Liver Grafts Promotes Liver Regeneration and Inhibits Tissue Inflammation
Background & aim: liver transplantation I/R injury is associated with inflammation, affecting graft outcome. Ex-vivo normothermic machine perfusion (NMP) to donor livers before transplantation reduces…2015 American Transplant Congress
Th17-Mediated Alloimmune Responses Play a Key Role in Intestinal Allograft Rejection in Humans
The Georgetown Transplant Institute, Washington, DC.
The majority of transplanted intestines still falls victim to allograft enteropathy, the underlying mechanisms of which are poorly understood. The purpose of this study was…2015 American Transplant Congress
Human iPS Cell-Derived Pancreatic β-Cells Correct Hyperglycemia in Diabetic Mice
Type I diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells. The consequences of T1D are dysregulation of metabolism leading…2015 American Transplant Congress
Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation
Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…2015 American Transplant Congress
Diminished Survival After Simultaneous Liver-Kidney Transplant With Increasing Kidney Donor Profile Index Score
Transplant Center, University of Texas Health Science Center, San Antonio, TX.
BACKGROUND: Since the introduction of MELD, the number of simultaneous liver-kidney (SLK) transplants has greatly increased. Renal failure after liver transplant is associated with a…2015 American Transplant Congress
MicroRNA (miR) 144 Dysregulates TGFβ Signaling Cascade and Contributes to Development of BOS Following Human Lung Transplantation
1Surgery, Washington Univ Sch Med, St. Louis, MO; 2Medicine, Washington Univ Sch Med, St. Louis, MO.
Background: Bronchiolitis Obliterans Syndrome (BOS) is characterized by a fibroproliferative cascade that is not amenable to current treatment regimens and remains the major impediment for…2015 American Transplant Congress
Belatacept-Treated Patients Had Better Graft Survival at 7-Years Post-Transplant Compared With Cyclosporine-Treated Patients: Final Results from BENEFIT
Background: At 3yrs, improvement in renal function was seen in kidney transplant recipients treated with belatacept (bela) vs cyclosporine (CsA) in BENEFIT. Here we report…2015 American Transplant Congress
B-Cell Tolerance to Donor Alloantigens
Pre-existing panel-reactive antibodies and development of donor-specific alloantibodies are known to play important roles in graft dysfunction and deterioration. Preventing and/or eliminating alloantibody responses would…2015 American Transplant Congress
ASKP1240 in De Novo Kidney Transplant Recipients
Primary objective was to evaluate the efficacy and safety of ASKP1240, antagonistic anti-CD40 antibody, in either a CNI free regimen or a CNI minimization regimen…
American Transplant Congress abstracts