Abstracts Archive - Page 1353 of 1683 - ATC Abstracts

2015 American Transplant Congress
Toxoplasmosis Post-Kidney Or Liver Transplantation: A Serie of Cases
L. Pierrotti, R. Salles, M. Rytholz, L. Azevedo, A. Song, L. D'Albuquerque, E. David-Neto, W. Nahas, E. Abdala.
Infectious Diseases, Kidney and Digestive Organs Transplantatiion, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.
Toxoplasmosis is a rare complication post-SOT, occurring mostly in D+/R- mismatch. However, in highly endemic areas, the disease occurs predominantly in R+ under post-tx immunosuppressive…
2015 American Transplant Congress
Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection
A. Gareau,¹ I. Gibson,² C. Wiebe,¹ J. Ho,¹ D. Rush,¹ P. Nickerson.¹
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Pathology, University of Manitoba, Winnipeg, MB, Canada.
Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…
2015 American Transplant Congress
Predicting Graft Loss in a Population of Kidney Transplant Patients Diagnosed With ABMR/TG
J. Reeve,¹ P. Halloran.¹
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
ABMR is the main cause of late graft loss in kidney transplants. Our goal was to determine the variables most strongly predictive of graft loss…
2015 American Transplant Congress
Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant
W. Zhang,¹ Z. Yi,¹ Z. Li,¹ M. Menon,¹ L. Li,¹ C. Xi,¹ I. Greene,¹ C. Wei,¹ L. Gallon,² M. Samaniego,³ A. Djamali,⁴ S. Alexander,⁵ B. Schroppel,¹ B. Nankivell,⁵ J. Chapman,⁵ I. Rosales,⁶ R. Neal Smith,⁶ R. Colvin,⁶ P. O'Connell,⁵ P. Heeger,¹ B. Murphy.¹
¹Icahn School of Medicine at Mount Sinai, New York; ²North Western University, Chicago; ³University of Michigan, Michigan; ⁴University of Wisconsin, Madison; ⁵The University of Sydney, Sydney, Austria; ⁶Massachusetts General Hospital, Boston.
Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…
2015 American Transplant Congress
Urinary CXCL10 Independently Improves the Noninvasive Diagnosis of Antibody-Mediated Kidney Allograft Rejection
M. Rabant,^1,2 L. Amrouche,^2,3 X. Lebreton,³ F. Aulagnon,³ A. Benon,² V. Sauvaget,² R. Bonifay,² L. Morin,³ A. Scemla,³ M. Delville,³ F. Martinez,³ M. Timsit,⁴ J. Duong Van Huyen,¹ C. Legendre,³ F. Terzi,² D. Anglicheau.^2,3
¹Pathology Department, Necker Hospital, Paris, France; ²INSERM U1151, Necker Hospital, Paris, France; ³Kidney Transplant Center, Necker Hospital, Paris, France; ⁴Urology Department, Necker Hospital, Paris, France.
The urinary levels of CXCL9 and CXCL10 can noninvasively diagnose T cell-mediated rejection (TCMR) of renal allografts. Their performance as diagnostic/prognostic markers of antibody-mediated rejection…
2015 American Transplant Congress
Non-Invasive Diagnosis of Post Kidney Transplant Complications by Urinary Exosomal mRNA Analysis
H. Harada,¹ T. Murakami,² C. Yamamoto,² M. Mitsuhashi.²
¹Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; ²Hitachi Chemical Research Center, Inc., Irvine, CA.
IntroductionMonitoring of kidney allograft status is important for the graft longevity. Conventional urinary markers are not sensitive and specific enough to diagnose graft injuries so…
2015 American Transplant Congress
The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation
S. Verma, Y. Tanaka, S. Shimizu, L. Das, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…
2015 American Transplant Congress
Intra-Renal Cytokine Measurement Detected During Kidney Allograft Biopsies Portend Severity of Histological Injury
N. Leca, S. Anderson, K. Muczynski.
Division of Nephrology, University of Washington, Seattle, WA.
Histological changes observed on renal allograft biopsies, although considered the current standard for evaluation of allograft injury, lack specificity and disease activity assessment. We devised…
2015 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy Targeting Ischemia/Reperfusion Injury in Heart Transplantation
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Aeromics, LLC, Cleveland, OH.
Aquaporin 4 (AQP4) belongs to the family of small integrin transmembrane proteins that are highly permeable to water. It was recently shown that human and…
2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
M. Martina,¹ S. Bandapalle,² S. Noel,² A. Saxena,¹ A. Hamad,¹ H. Rabb.²
¹Pathology, Johns Hopkins University, Baltimore, MD; ²Medicine, Johns Hopkins University, Baltimore, MD.
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…