2015 American Transplant Congress
Tobacco Use Is a Significant Risk Factor for Post-Transplant Biliary Complications
Surgery, University of Rochester Medical Center, Rochester, NY.
Purpose: Biliary complications following liver transplantation are a significant source of morbidity, potentially leading to graft failure necessitating retransplantation. Smoking precipitates both microvascular and macrovascular…2015 American Transplant Congress
Post-Liver Transplant Delirium Is Associated With Increased Mortality and Prolonged Length of Stay
Delirium after liver transplantation (LT) has been reported to increase ICU and hospital length of stay, but limited information is available regarding the incidence, potential…2015 American Transplant Congress
Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients
Introduction: Calculations used to determine expected survival post-liver transplant (OLT) are in part based on pre-OLT functional status. Functional status is subjectively measured by Karnofsky…2015 American Transplant Congress
National Transplantation Pregnancy Registry: Cholestasis of Pregnancy in Liver Transplant Recipients
Cholestasis of pregnancy (COP) occurs in approximately 1% of pregnancies and is associated with increased risk of premature delivery. The purpose of this study was…2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…2015 American Transplant Congress
B7-H1 Deficiency in Liver Allografts Leads to CD8-Mediated Acute Vascular Rejection
The liver is a unique organ in that it is accepted across complete MHC mismatch in allotransplantation in a number of species. The mechanisms behind…2015 American Transplant Congress
Alloantibody-Dependent Macrophage-Mediated Hepatocellular Damage Is Dependent on FcγRI, FcγRIII, and Reactive Oxygen Species
Dept of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
Alloantibodies (alloAb) play a critical role in rejection after transplantation. Despite this, the cellular mechanisms contributing to alloAb-mediated allograft damage are not well understood. Using…2015 American Transplant Congress
Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway
The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…2015 American Transplant Congress
Notch Signaling Mediates Epithelial-to-Mesenchymal Transition in the Development of Marginal Liver Graft Fibrosis
Depatment of Surgery, The University of Hong Kong, Hong Kong, China.
Background and aims:Although graft size and chronic liver diseases have been proposed as risk factors for post-transplantation liver fibrosis, the underlying mechanisms remained unclear. Our…2015 American Transplant Congress
Galectin-9 Protects Mouse Liver Transplants Against Ischemia-Reperfusion Injury
Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA.
Background:Although Galecin 9 (Gal-9) negatively regulates Th1-type alloimmunity by binding to T-cell Immunoglobulin Mucin-3 (TIM-3) on activated Th1 cells, its role in liver ischemia-reperfusion injury…
American Transplant Congress abstracts