2015 American Transplant Congress
Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation
[Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…2015 American Transplant Congress
CN Inhibition (But Not mTOR Inhibition) of a Novel CD8+ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant
Department of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
MTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressive drugs commonly used to suppress the rejection of transplanted organs and tissues.…2015 American Transplant Congress
Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens
Transplant Unit, Hiroshima University, Hiroshima, Japan.
Aim: Bacterial infection following ABO-incompatible organ-transplantation is associated with refractory Ab-mediated rejection. Here, we investigated the influence of toll-like receptor (TLR)-signaling, via the binding of…2015 American Transplant Congress
Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies
1University of Alberta, Edmonton, Canada; 2Imperial College, London, United Kingdom.
Background: In 2013, the Banff classification adopted molecular diagnostics as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. The NanoString gene…2015 American Transplant Congress
Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition
Department of Surgery, CTC, The Ohio State University, Columbus, OH.
mTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressives commonly used to suppress rejection of transplants. Despite widespread use following transplantation…2015 American Transplant Congress
Passive Administration of Antibodies to Cardiac Myosin Immediately Following Syngenic Cardiac Transplantation Result in Rejection
Surgery, Washington Univ Sch of Med, St. Louis, MO.
Introduction: Auto-immune responses to cardiac myosin, a heart specific protein has been proposed to be a target auto-antigen resulting in cardiac allograft vasculopathy following transplantation.…2015 American Transplant Congress
Rise in Deceased Donors Labeled "Increased Risk for Disease Transmission" Under New Guidelines
Deceased donors are labeled increased infectious risk (IRD) if they meet certain criteria; however, stigma, legal and regulatory burden to centers, and decreased organ utilization…2015 American Transplant Congress
Does DSA Market Competition Influence OPO Performance?
INTRODUCTION: Increased market competition within a Donor Service Area (DSA) is associated with a greater number of liver and kidney transplants, but its effect on…2015 American Transplant Congress
The Economic Impact of Nonimmune Complications in Contemporary Kidney Transplantation
The clinical burden and economic impacts of nonimmune complications after kidney transplant (KT) are incompletely defined.We examined United States Renal System Registry Data for Medicare-insured…2015 American Transplant Congress
Failure to Account for Critical Candidate Characteristics Significantly Biases Kidney Transplant Center Report Cards Measuring Time to Transplant
1Surgery, Montefiore Medical Center, Bronx, NY; 2Medicine, Cleveland Clinic, Cleveland, OH.
Kidney transplant rate is proposed to be integrated into the new composite metric to evaluate center performance. Current methods adjust for PRA, blood type, re-transplantation,…
American Transplant Congress abstracts