ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.

    M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.

    University of Florida, Gainesville, FL.

    Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
  • 2016 American Transplant Congress

    Donors with Isolated Anti-HBc (“HBcAb Only”) Antibodies: True Evidence for Past Infection or Laboratory Artifact? Toward a Simple Confirmatory Test for HBcAb.

    Y. Chang,1,3 C. Chinchilla-Reyes,2 M. Koss,1,2 M. Nowicki.1,2

    1Mendez National Institute of Transplantation Foundation, Los Angeles, CA; 2Viracor-IBT Laboratories, Los Angeles, CA; 3Western University of Health Sciences, Pomona, CA.

    Use of organs from donors positive for hepatitis B virus (HBV) markers may safely expand the donor pool. Recently the American Society of Transplantation expert…
  • 2016 American Transplant Congress

    Kidney Retransplantation Is Associated with Higher Mortality Risk Among HIV+ vs. HIV- Recipients.

    B. Shelton,1 S. Mehta,1 D. Sawinski,2 R. Reed,1 P. MacLennan,1 S. Gustafson,3 C. Durand,4 D. Segev,4 J. Locke.1

    1School of Medicine, University of Alabama at Birmingham, Birmingham, AL; 2School of Medicine, University of Pennsylvania, Philadelphia, PA; 3Scientific Registry of Transplant Recipients, Minneapolis, MN; 4School of Medicine, Johns Hopkins University, Baltimore, MD.

    Background: Excellent outcomes have been demonstrated in HIV+ kidney transplant (KT) recipients, yet no study has explored outcomes among HIV+ reKT recipients.Methods: 4,683 adult reKT…
  • 2016 American Transplant Congress

    The Use of Sofosbuvir (SOF)-Containing Direct Antiviral Agents (DAA)-Based Regimens Requires Increase in Tacrolimus (Tac) Doses in Kidney Transplant (KT) Recipients with Hepatitis C Virus (HCV) Infection.

    N. Polanco Fernandez,1 A. García Santiago,1 M. Fernández Ruiz,2 R. Muñoz,3 C. Alvarez Vazquez,4 A. Hernandez,1 V. Mercado,1 E. González Monte,1 I. Fernández,3 J. Aguado,2 M. Praga,1 A. Andres.1

    1Nephrology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 2Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Madrid, Spain; 3Gastroenterology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 4Biochemistry, Hospital Universitario “12 de Octubre”, Madrid, Spain.

    Background: The use of SOF-containing regimens based on NS5A inhibitors has not been shown interactions with Tac in liver transplant.Specific data on KT recipients are…
  • 2016 American Transplant Congress

    Efficacy and Safety of Direct Antiviral Agents (DAA)-Based Therapies for Hepatitis C Virus (HCV) Infection in Kidney Transplant (KT) Recipients.

    M. Fernandez Ruiz,1 A. García Santiago,2 N. Polanco Fernandez,2 R. Muñoz,3 A. Hernandez,2 E. González Monte,2 V. Mercado,2 I. Fernández,3 J. Aguado,1 M. Praga,2 A. Andrés.2

    1Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Madrid, Spain; 2Nephrology, Hospital Universitario “12 de Octubre”, Madrid, Spain; 3Gastroenterology, Hospital Universitario “12 de Octubre”, Madrid, Spain.

    Background: The use of interferon-based regimens for HCV infection in KT recipients is limited due to the increased risk of acute graft rejection (AR), poor…
  • 2016 American Transplant Congress

    Utilization of HCV-Positive Donors' Kidneys: Potential Benefits in the Era of Direct Acting Antiviral (DAA) Therapy.

    B. Amundsen,1 M. Sise,2 M. Lin,3 H. Deirawan,1 E. Heher,2 B. Kimball,1 J. Markmann,1 N. Elias.1

    1Massachusetts General Hospital, Boston, MA; 2Massachusetts General Hospital, Boston, MA; 3Brigham and Women's Hospital, Boston, MA.

    Organ shortage and expanding kidney waiting list fostered utilization of HCV positive donors' organs (HCVD+). HCVD+ kidneys have slightly worse long term outcomes compared with…
  • 2016 American Transplant Congress

    Exosomes with Lung Associated Self-Antigens (Collagen V and K alpha 1 Tubulin): Role in Rejection Following Human Lung Transplantation.

    M. Gunasekaran,1,2 Z. Xu,1,2 D. Nayak,1,2 M. Sharma,1,2 R. Hachem,1 T. Mohanakumar.1,2

    1Surgery, Pathology & Immunology, & Medicine, Washington Univ Sch Med, St. Louis, MO; 2Norton Thoracic Institute - St. Joseph's Hospital, Phoenix, AZ.

    Immune response to HLA and non-HLA antigens play a significant role in the development of chronic and acute rejection (AR), bronchiolitis obliterans syndrome (BOS), following…
  • 2016 American Transplant Congress

    Microarray Analysis of Transbronchial and Mucosal Biopsies in Lung Transplant Recipients Detects Molecular Changes of T-Cell Mediated Inflammation.

    K. Halloran,1 J. Chang,2 V. Ramassar,2 J. Weinkauf,1 A. Kapasi,1 D. Lien,1 J. Reeve,2 P. Halloran.1,2

    1Medicine, University of Alberta, Edmonton, Canada; 2Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada.

    Purpose: The main diagnostic platform for rejection in lung transplant recipients is histology of transbronchial biopsies (TBB), a test with a poor performance and safety…
  • 2016 American Transplant Congress

    High-Risk Age Window for Graft Loss in Pediatric Lung and Heart Transplant Recipients.

    B. Orandi, X. Luo, K. Van Arendonk, R. Higgins, D. Segev.

    Johns Hopkins University, Baltimore.

    Late adolescence and early adulthood is a high-risk age window for pediatric kidney graft loss, though not for pediatric liver graft loss. It is unknown…
  • 2016 American Transplant Congress

    Resolution of Undefined Etiology of Respiratory Infections in Lung Transplant Patients with Unbiased Metagenomic Sequencing.

    N. Mueller,1 D. Lewandowska,2 B. Ruehe,2 P. Schreiber,1 O. Zagordi,2 F. Geissberger,2 M. Schuurmans,3 M. Greiner,1 A. Zbinden,2 J. Boeni,2 C. Benden,3 A. Trkola,2 M. Huber.2

    1University Hospital Zurich, Division of Infectious Diseases, Zurich, Switzerland; 2University of Zurich, Institute of Medical Virology, Zurich, Switzerland; 3University Hospital Zurich, Division of Pulmonary Medicine, Zurich, Switzerland.

    Study Purpose A high number of post-transplant infections with respiratory symptoms remain unresolved, despite routine testing for the common respiratory viruses. Using an open metagenomic…
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