2016 American Transplant Congress
αLFA-1 Monotherapy Induced Tolerance Is Dependent on Indirect CD8 T-Cells and Augments a Population of CD8 Cells with a Suppressor Phenotype.
We sought to investigate some of the requirements for tolerance induction to cardiac allografts utilizing αLFA-1 mAb monotherapy. Having previously demonstrated that CD8 T-cells are…2016 American Transplant Congress
Role of Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Osteomyocutaneous Allotransplantation Under Combined Costimulation Blockade.
Background: The role of regulatory T cells (Tregs) in allograft tolerance has been studied using various transplant models, but the mechanism in vascularized composite allotransplantation…2016 American Transplant Congress
Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.
Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…2016 American Transplant Congress
Mechanisms of Alloantigen-Specific Regulation After Donor Specific Transfusion and Costimulatory Blockade in YFP-Foxp3/TdTomRed-Ebi3 Marker Mice.
Background: In mice, donor specific transfusion (DST) plus anti-CD40L costimulatory blockade (MR-1) treatment is a standard and successful protocol to induced donor-specific transplant tolerance. Hypothesis:…2016 American Transplant Congress
Evaluation of a Novel Global Immunity Assay to Predict Infections in Organ Transplant Recipients.
Multi-Organ Transplant, University Health Network, Toronto, Canada.
BackgroundSimple standardized measures of global immunity may help predict the risk of infections post-transplant. The Quantiferon-Monitor (QFM) test is a novel interferon-γ (IFN-γ) release assay…2016 American Transplant Congress
Diversity of Influenza Antibody Repertoire in Transplant Recipients with Natural Influenza Infection.
Multi-Organ Transplant, UHN, Toronto, Canada.
Background: The nature of the immune response to seasonal Influenza A Virus infection has not been well characterized in transplant patients. Antibodies may be directed…2016 American Transplant Congress
Early Conversion to Everolimus in De Novo Renal Transplant Recipients: Incidence of Viral Infections in the Randomized-Controlled ELEVATE Study.
BackgroundCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections are independent risk factors for acute rejection and graft loss. Early conversion from calcineurin inhibitors (CNIs) to everolimus…2016 American Transplant Congress
Assessment of Chikungunya IgM Prevalence Among Deceased Organ and Tissue Donors Using Two Enzyme Immunoassay (EIA) Kits.
Viracor-IBT Laboratories, Los Angeles, CA.
Study Purpose: The emergence of Chikunungya virus (ChikV) infection in the western hemisphere has raised concerns of donor-derived transmission. We assessed the prevalence of recent…2016 American Transplant Congress
Viral Gastroenteritis in Adult and Pediatric Solid Organ Transplant (SOT) Patients.
BACKGROUND. Diarrhea in SOT recipients is common and often attributed to immunosuppressive drug side effects. However, enteric viruses are important causes of acute gastroenteritis and…2016 American Transplant Congress
One Year Post VZV Booster: Still Equal Response in Renal Transplant Recipients Compared to Healthy Persons.
Introduction: Herpes zoster occurs more frequently and with more complications in solid organ transplant recipients than in age matched healthy persons. Vaccination could prevent herpes…
American Transplant Congress abstracts