2016 American Transplant Congress
Absence of Host CD137 Signaling Converts Chronic GVHD Toward Acute GVHD.
CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…2016 American Transplant Congress
Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.
BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…2016 American Transplant Congress
ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.
BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…2016 American Transplant Congress
Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.
Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…2016 American Transplant Congress
In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells – A Novel Approach for Tolerance Induction in Transplantation.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.
Background: Cell-based therapies represent a new promising approach for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…2016 American Transplant Congress
Inflammatory Conditions Switch the Effect of MSC on B Cells from Pro-Tolerogenic to Anti-Proliferative.
The immunomodulatory capacity of mesenchymal stem cells (MSC) makes them a promising therapeutic tool in transplantation. MSC are recently gaining interest for their immunomodulatory effects…2016 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cell Transplantation in a Cirrhotic Liver Rat Model.
Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Previous studies suggested that MSCs may ameliorate fibrogenesis through…2016 American Transplant Congress
Chimeric Cell Transplantation for Treatment of Duchenne Muscular Dystrophy: A Preliminary Report.
Orthopaedic Surgery, University of Illinois at Chicago, Chicago.
Background: Transplant of Chimeric Cells, created via ex vivo fusion of donor and recipient cells, represents a promising cell therapy option in the field of…2016 American Transplant Congress
FGF and Wnt Signaling in Pancreatic Progenitor and Beta-Cell Growth.
Beta-cell replacement therapy offersa cure for diabetes, but this is limited by the lack of readilyavailable supply of cells. Our goal is generate enough beta-cells…2016 American Transplant Congress
Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.
Mesenchymal stromal cells (MSC) are candidates for immunotherapy after transplantation. MSC have shown to be immunomodulatory and low immunogenic, which is favorable for cellular therapy…
American Transplant Congress abstracts