2016 American Transplant Congress
Successful Human-to-NonHuman Primate Pancreatic Islet Intraportal Xenotransplantation Using a Human Allo-Based Immunosuppression Regimen and Its Potential Pre-Clinical Application.
Intraportal pancreatic islet cell transplantation is a successful treatment for type-1 diabetes (T1DM) in humans. Unfortunately, the lack of donor pancreatic organs is a major…2016 American Transplant Congress
Multiplex Profiling of Plasma Proteins After Xenogenic Lung Exposure.
Background: Porcine lungs exhibit injury by human blood and are only partially protected in GalTKO organs with additional human membrane cofactor protein (hCD46). Residual injury…2016 American Transplant Congress
Human PDL1+ SLA-DR– Swine Vascular Endothelial Cells Suppress Pig-Human PBMC Xeno-MLR(Mixed Lymphocyte Reaction) by Inducing Human Regulatory IL-10+Tr1(Type 1 Regulatory T Cells) Subset for Suppression of Xenogeneic Reactions.
Type 1 regulatory T cells(Tr1) are active in transplantation tolerance. The Tr1 cells are inducible in our lab from human CD4 T cells (hCD4 T)…2016 American Transplant Congress
A Novel Humanized Mouse Model Incorporating Non-Fetal Tissue.
Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.
Pre-clinical research into allogeneic tissue transplantation therapies, as well as patient-specific regenerative medicine studies, require animal models that closely mimic the typical patient's immune response.…2016 American Transplant Congress
Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4+CD25+FoxP3+ Treg Cells.
Introduction: We have shown that porcine islets engineered to transiently display SA-FasL protein on their surface establish tolerance in mice following transplantation under the kidney…2016 American Transplant Congress
A Novel Inflammation-Targeting Tacrolimus Hydrogel for Liver Transplantation.
Background:Immunosuppressant have played a critical role for improving graft survival after liver transplantation (LT). While long-term systemic use of immunosuppressant such as tacrolimus (FK506) is…2016 American Transplant Congress
Function of Sertoli Cells in Regulating Allogeneic T Cell Differentiation into Treg and Th17 In Vitro.
The testis as an immune-privileged site allows long-term survival of allogeneic and xenogeneic transplants. Testicular Sertoli cells (SCs) can confer local immunoprotection for cotransplanted cells…2016 American Transplant Congress
Evaluation of Conformational Diversity of a Single HLA-I Molecule Coated on Single Antigen Beads: Potential Impact on Organ Allocation?
Terasaki Foundation Laboratory, Los Angeles, CA.
Recombinant HLA-I (rHLA-I) molecules are the antigenic targets used to screen HLA-I DSA in the sera of pre- or post-transplant patients. A conformational diversity, β2-microglobulin-associated…2016 American Transplant Congress
One-Year Graft Loss Risk in Kidney Transplants – A Big Data Approach.
MUSC, Charleston, SC; IBM Corp., Armonk.
Background Predictive models using national data are limited by lack of evolving patient level data. A Big Data approach using both static and dynamic variables…2016 American Transplant Congress
Neighborhood Poverty and Gender Disparities in Access to Live Donor Kidney Transplantation.
Women are less likely to receive a live donor kidney transplant (LDKT) than men, but little is known about the contribution of poverty to this…
American Transplant Congress abstracts