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American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Development of Diabetic Glomerulosclerosis (DMGS) After Kidney Transplantation (KTX).

    F. Cosio, L. Cornell, M. Stegall.

    Transplant Center, Mayo Clinic, Rochester, MN.

    Introduction. Causes of death-censored KTX loss are multiple and often non-alloimmune mediated. Examination of KTX biopsies after 5 years revealed an increasing number of cases…
  • 2016 American Transplant Congress

    A 30% Decrease in Post-kidney Transplant Estimated Glomerular Filtration Rate (eGFR) from 6 Mo-2 Y Is a Surrogate for 5 Y eGFR: Results from Clinical Trials in Organ Transplantation-(CTOT)-17.

    G. Faddoul,1 G. Nadkarni,1 D. Hricik,2 P. Heeger,1 CTOT17 Investigators.

    1Medicine and Recanati Miller Transplant Institute, Icahn School of Medicine, NY, NY; 2Medicine, Case Medical Center, Cleveland, OH.

    Predicting long-term kidney allograft outcomes using early clinical/biomarker data could guide individualized therapy. Emerging evidence in progressive native kidney disease indicates >30% decrease in eGFR…
  • 2016 American Transplant Congress

    Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.

    S. Yilmaz,1 D. Shaffer,2 Y. Qazi,3 F. Shihab,4 K. McCague,5 D. Patel,5 F. Vincenti.6

    1University of Calgary, Calgary, AB, Canada; 2Vanderbilt University, Nashville, TN; 3University of Southern California, Los Angeles, CA; 4University of Utah, Salt Lake City, UT; 5Novartis Pharmaceuticals Corporation, East Hanover, NJ; 6University of California San Francisco, San Francisco, CA.

    Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
  • 2016 American Transplant Congress

    Renal Graft Survival According to Banff 2013 Diagnostic Categories in Indication Biopsies.

    D. Redondo-Pachón,1 C. Arias-Cabrales,1 M. Pérez-Sáez,1 J. Gimeno,2 I. Sánchez-Güerri,2 S. Bermejo,1 A. Sierra,1 C. Burballa,1 M. Mir,1 M. Crespo,1 J. Pascual.1

    1Nephrology, Hospital del Mar, Barcelona, Spain; 2Pathology, Hospital del Mar, Barcelona, Spain.

    The impact of acute rejection in kidney graft survival is well known, but the prognosis of other diagnosis is uncertain. We evaluated the frequency and…
  • 2016 American Transplant Congress

    Sequential and Long-Term Protocol Biopsy Is Useful for the Detection of Subclinical Lesions of Clinical Interest in Kidney Allografts.

    M. Miura,1 H. Higashiyama,1 T. Tsuji,2 Y. Fukasawa.2

    1Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; 2Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.

    Objectives: Detection of subclinical lesions is important to overcome the obstacles to improve long-term graft survival after kidney transplantation. The aim of this study was…
  • 2016 American Transplant Congress

    Cold Ischemia Induced Outcomes in Kidney Transplantation: A Meta-Analysis.

    D. Bennett, M. Mustafa, M. Chiles, W. Skillen, S. Mohan.

    Columbia University Medical Center, New York, NY.

    Objective: To examine the association between cold ischemia time (CIT) and delayed graft function (DGF) and death-censored graft failure in kidney transplantation.Methods: To identify relevant…
  • 2016 American Transplant Congress

    Early Onset Hyperuricemia Is a Prognostic Marker for Kidney Allograft Dysfunction.

    M. Han,1 S. Yang,2 I. Jung,3 S.-K. Park,4 Y. Kim,5 D. Han,5 Y. Kim,1 S. Kim,6 J. Lee.7

    1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; 2Kidney Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; 3Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; 4Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea; 5Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea; 6Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; 7Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

    Aim: It is not certain whether hyperuricemia is a true risk factor of kidney allograft failure. We investigated the association of hyperuricemia and graft outcome.Methods:…
  • 2016 American Transplant Congress

    Fluctuation of Renal Function During the First Year Is Associated with Negative Impact on Long-Term Kidney Graft Survival: A Retrospective, Propensity Score-Matched Study.

    H. Choi,1 D. Joo,2,3 M. Song,4 M. Kim,2,3 Y. Kim,2,3 B. Kim.1,3

    1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 3The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 4Department of Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea.

    Background: Post-transplant renal function in the first year has been reported to predict long-term renal graft survival. The present study examined whether the fluctuation of…
  • 2016 American Transplant Congress

    Do Highly Sensitized Recipients Benefit from the Immunological Advantages of Zero Mismatched (0MM) Deceased Donors (DD) Kidney Allografts?

    N. Elfadawy,1 S. Flechner,2 J. Schold.2

    1Internal Medicine, Case Western Reserve University, Cleveland, OH; 2Glickman urological and kidney institute, Cleveland Clinic, Cleveland, OH.

    HLA 0MM DD transplants have superior outcomes compared with outcomes for grafts with ≥1 HLA mismatches, but when past reports analyzed 0MM outcomes in DD,…
  • 2016 American Transplant Congress

    Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury.

    K. Schuette-Nuetgen,1 G. Thölking,1 H. Pavenstädt,1 S. Ehlert,1 B. Suwelack,1 D. Palmes,2 R. Bahde,2 S. Reuter.1

    1Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, Muenster, Germany; 2Department of General and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.

    Given the gap between patients in need of a kidney transplantation and organs available, transplantation centers increasingly accept lower quality organs, e.g. from donors with…
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