2016 American Transplant Congress
Learning from Cancer: Using D-Lactate for Therapeutic Immunosuppression.
Accumulation of lactic acid in the tumor microenvironment contributes to local immunosuppressive conditions that weaken anti-tumor immunity. Lactic acid exists as L- and D- optical…2016 American Transplant Congress
The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade.
Center for Transplantation Science, Massachusetts General Hospital, Boston, MA.
Background:Regulatory T cell (Treg) immunotherapy has been applied to minimize the immunosuppressive drugs in clinical transplantation. To avoid contamination of CD4+CD25- T cells, only highly…2016 American Transplant Congress
CXCL12 as Innovative Immune Isolating Chemokine for Microencapsulated Allo and Xeno-Transplantation in NHPs.
Introduction The purpose of this study is to determine whether a clinical-grade alginate-microencapsulant incorporating CXCL12, can protect and sustain the function of allo and/or adult…2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…2016 American Transplant Congress
Resveratrol Effectively Suppress Th17 Associated Allo-Immune Responses by the Modulation of AMPK/mTOR Pathway.
The aim of this study is to investigate the effect of resveratrol on Th17 allo-immune responses under tacrolimus (Tac)-based immune suppression. First, we investigated the…2016 American Transplant Congress
End-Stage Renal Disease Does Not Impair the Large-Scale Generation of Potent Alloantigen-Specific Regulatory T Cells for Immunotherapy.
Background Alloantigen-specific natural occurring regulatory T cells (nTregs) have the potential to offer a more targeted approach of immunosuppression and are the cell type of…2016 American Transplant Congress
Characterization of T Regulatory Type 1 (Tr1) Cells in Naïve and Transplanted Non-Human Primates.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
BackgroundT regulatory Type 1 (Tr1) cells are peripheral CD4+FoxP3- regulatory T cells expressing CD49b and LAG-3 in mice and humans. Mouse Tr1 cells inhibit antigen-presenting…2016 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2016 American Transplant Congress
Ex Vivo Expansion of Human Alloantigen-Reactive Regulatory T Cells Using Monocyte-Derived Dendritic Cells versus CD40L-Stimulated B Cells.
Background:Alloantigen-reactive murine and human CD4+CD25+FOXP3+ regulatory T cells (arTreg) are more potent in promoting long-term allograft survival than polyclonal Treg in experimental models. Dendritic cells…2016 American Transplant Congress
Impact of Immunosuppressants on Inducing Regulatory T Cells in Human Allo-Immune Responses.
Transplant Surgery, Hiroshima University, Hiroshima, Japan.
A better understanding of cytokine signaling pathways involving transcription factors of the STAT family in T cells responding to allostimulation will improve interpretation of immune-regulatory…
American Transplant Congress abstracts