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  • 2016 American Transplant Congress

    Black Ethnicity as a Risk Factor for Poor Kidney Allograft Outcomes Post-Transplantation.

    S. Tahir,1 F. Jackson-Spence,1 H. Gillott,1 F. Everson,2 J. Nath,2 A. Sharif.2

    1University of Birmingham, Birmingham, United Kingdom; 2Queen Elizabeth Hospital, Birmingham, United Kingdom.

    Introduction: Registry studies, largely from the United States, have consistently demonstrated inferior outcomes for black patients undergoing renal transplant. A recent Canadian publication has challenged…
  • 2016 American Transplant Congress

    Safety of a Short (One-Year) Waiting Time in Kidney Transplant Candidates Treated for Cancer.

    D. Dahle,1 T. Grotmol,2 T. Leivestad,3 A. Hartmann,1 G. Mjøen,1 H. Pihlstrøm,1 H. Næss,1 H. Holdaas.1

    1Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway; 2The Cancer Registry of Norway, Oslo, Norway; 3Norwegian Renal Registry, Oslo University Hospital, Oslo, Norway.

    In Norway, a one-year waiting time free of cancer recurrence is required before kidney transplantation. To provide an updated, large-scale assessment of this practice, the…
  • 2016 American Transplant Congress

    Utilization and Discard of HCV+ Donor Livers in the Advent of Direct-Acting Antiviral Therapy.

    M. Bowring, L. Kucirka, A. Massie, X. Luo, M. Sulkowski, D. Segev, C. Durand.

    JHU, Baltimore.

    While 45% of liver candidates are hepatitis C (HCV)-antibody positive (+) and might benefit from a HCV+ donor liver, only a small proportion receive one.…
  • 2016 American Transplant Congress

    Hepatitis E Virus (HEV) Infection Among Kidney Transplant Patients in a Northeast US Center.

    M. Lim,1 S. Kamili,2 T. Greene,2 A. Tejada-Strop,2 J. Drobeniuc,2 M. Vanderveen,1 R. Bloom.1

    1Division of Nephrology, Perelman School of Medicine, Philadelphia, PA; 2Division of Viral Hepatitis, Centers for Disease Control, Atlanta, GA.

    Aim. To determine the prevalence of HEV infection in kidney candidates and assess chronic HEV infection among transplant recipients. Methods. We recruited 244 kidney transplant…
  • 2016 American Transplant Congress

    An Economical and Effective Vaccination Program in Patients Transplanted for Hepatitis B Virus Related Liver Diseases: A Prospective Study.

    W. Ju, A. Yang, Q. Ren, D. Wang, Z. Guo, Y. Ma, A. Hu, Q. Tai, X. Zhu, X. He.

    Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Aims: To prospectively investigate the efficacy and safety of procedural HBV vaccination in patients transplanted for HBV related liver diseases for prevention of hepatitis B…
  • 2016 American Transplant Congress

    High Efficacy of Ledipasvir/Sofosbuvir with Ribavirin in HCV Genotype-1 Infected Patients with Decompensated Liver Disease: Analysis by MELD Score from the SOLAR-1 and SOLAR-2 Trials.

    M. Charlton,1 E. Yoshida,2 M. Bouliere,3 S. Flamm,4 A. Muir,5 M. Fried,6 N. Terrault,7 S. Arterburn,8 C. Yun,8 P. Pang,8 A. Osinusi,8 J. Spellman,8 M. Natha,8 D. Brainard,8 J. McHutchison,8 M. Manns,9 N. Afdhal.10

    1Intermountain Medical Center, Salt Lake City; 2Vancouver General Hospital, Vancouver, Canada; 3Hopital Saint Joseph, Marseilles, France; 4Northwestern University, Chicago; 5Duke University, Durham; 6University of North Carolina, Chapel Hill; 7UCSF, SF; 8Gilead Sciences Inc, Foster City; 9Hannover Medical School, Hannover, Germany; 10BIDMC, Boston.

    Introduction: HCV infected patients with decompensated liver disease have significant morbidity & mortality. The efficacy & safety of LDV/SOF + RBV was evaluated in a…
  • 2016 American Transplant Congress

    Time Course of Hepatic Graft Function Improvement After Ledipasivir/Sofosbuvir Treatment in Liver Transplant Recipients with HCV and Fibrosis or Cirrhosis Who Achieved SVR.

    S. Helmke,1 J. O'Leary,2 J. Burton,1 M. Cookson,1 S. Lauriski,1 J. Trotter,2 J. McHutchison,3 G. Everson.1

    1University of Colorado, Aurora, CO; 2Baylor University Medical Center, Dallas, TX; 3Gilead Sciences, Inc., Foster City, CA.

    Background: In SOLAR-1, liver transplant recipients with HCV and either fibrosis or cirrhosis were treated at baseline with ledipasvir/sofosbuvir and ribavirin for 12 or 24…
  • 2016 American Transplant Congress

    Decline of HCV RNA and Core Antigen: Predictors of Achieving SVR in Transplant Recipients Undergoing DAA-Therapy.

    S. Pischke,3 V. Proske,1 S. Polywka,4 M. Lütgehetmann,4 M. Lang,1 S. Stauga,1 L. Fischer,1 A. Lohse,3 B. Nashan,2 M. Sterneck.1

    1University Transplant Center, University Hospital Hamburg Eppendorf, Hamburg, Germany; 2Department of Hepatobiliary Surgery and Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany; 3Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Greece; 4Department of Microbiology, University Hospital Hamburg Eppendorf, Hamburg, Germany.

    Background:DAA-treatment of hepatitis C virus (HCV) re-infections in orthotopic liver transplant (OLT) recipients has been demonstrated to be safe and effective in controlled studies, but…
  • 2016 American Transplant Congress

    Large Single-Center Experience of Sofosbuvir and Ledipasvir Therapy for the Treatment of Post-Liver Transplant Patients with Hepatitis C Virus.

    J. Wedd, R. Ford, J. Norvell, S. Parekh, N. Cheng, N. Young, A. Patel, R. Maheshwari, R. Vora, O. Mgbemena, J. Spivey, A. Pillai.

    Medicine, Emory University, Atlanta, GA.

    Background/Aims: Controlled trials of direct acting antiviral therapy for Hepatitis C Virus (HCV) show impressive sustained virologic response (SVR) rates, but post-transplant data of sofosbuvir…
  • 2016 American Transplant Congress

    A Pathway to Belatacept Monotherapy: Alemtuzumab, Belatacept and Rapamycin for Kidney Transplantation.

    A. Guasch,1 H. Xu,2 A. Mehta,1 A. Ghali,1 S. Mead,1 H. Gebel,1 R. Bray,1 C. Larsen,1 T. Pearson,1 A. Kirk.2

    1Emory Transplant Center, Atlanta, GA; 2Duke University, Durham, NC.

    Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…
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