2017 American Transplant Congress
A Novel Endpoint for Evaluating the Effect of Everolimus with Reduced Calcineurin Inhibitor on Long-Term Kidney Graft Outcome: The TRANSFORM Study Protocol.
1TRANSFORM Study Group, Murray; 2Novartis Pharma AG, Basel, Switzerland
Purpose: With the advancement of immunosuppressive (IS) agents, while short-term graft outcomes improved significantly, long-term outcomes remain a concern. Both acute rejection (AR) and nephrotoxicity…2017 American Transplant Congress
Systemic Meta-Analysis: Is Early Conversion to mTOR Inhibitors Represent a Suitable Choice in Renal Transplant Recipients?
Aim: This meta-analysis focuses on the current evidence of renal graft functioning and graft survival following early conversion to mTOR inhibitors with or without CNI…2017 American Transplant Congress
Anti-CD25mAb Sparing Immunosuppressive Regimen Suppressed Recurrence of Post-Transplant Focal Segmental Glomerular Sclerosis- A Single Center Experience.
Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan
INTRODUCTION: The rate of recurrence of primary focal segmental glomerular sclerosis (FSGS) is problematic, because it often results in very early serious urinary protein secretion…2017 American Transplant Congress
Tacrolimus Pharmacogenomics: Association of Genetic Variants with Clinical Factors Including Tacrolimus Requirement, Clearance, Intraindividual Variability, and Coefficient Variation.
Background: Tacrolimus, which plays a backbone in immunosuppressive therapy, has a different effect in absorption according to intraindividual and interindividual variability, and it is a…2017 American Transplant Congress
Steroid Free Maintenance Immunosupression in Kidney Transplantation: Indiana University Experience.
Renal Transplant, Indiana University School of Medicine, Indianapolis, IN
Background: Steroid based maintenance Immunosuppression (IS) regimen is the standard protocol for many kidney transplant(tx) centers. However, concerns for chronic steroid impact on patients remains…2017 American Transplant Congress
More Than Renal Function: Use of Belatacept to Improve Drug Toxicities.
Background: Data with belatacept has demonstrated that patients on de novo belatacept have better renal function and improved patient and graft survival seven years post-transplant.…2017 American Transplant Congress
Conversion from Calcineurin Inhibitor to Sirolimus in Kidney Transplantation Recipients with Malignancy.
Nephrology, Asan Medical Center, Seoul, Republic of Korea
Background: Kidney transplant recipients are at an increased risk of malignancy for various reasons, such as the chronic use of calcineurin inhibitor (CNI). Sirolimus (SRL),…2017 American Transplant Congress
Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Dosing.
Bodyweight-based dosing of tacrolimus (Tac) is considered standard care, even though the available evidence is thin. An increasing proportion of transplant recipients is overweight, prompting…2017 American Transplant Congress
Single-Center, Prospective, Open Label Pilot Study to Investigate the Effectiveness of Everolimus Associated with Mycophenolic Acid and Prednisone in Adult Patients Submitted to an Allograft Renal Transplant with Calcineurin Inhibitor Withdrawl on Week 16th.
Although CI have proven efficacy in kidney transplantation worldwide, they are drugs with nephrotoxic potential and may contribute to chronic renal allograft nephropathy. As a…2017 American Transplant Congress
A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus.
Hospital das Clinicas FMUSP, Sao Paulo, Brazil
Mycophenolic acid(MPA) PK, from enteric-coated mycophenolate sodium(EC-MPS) has a broad range of Tmax avoiding the use a single concentration to calculate the area-under-the-time-concentration curve(AUC). Either…
American Transplant Congress abstracts