Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Mycophenolic acid(MPA) PK, from enteric-coated mycophenolate sodium(EC-MPS) has a broad range of Tmax avoiding the use a single concentration to calculate the area-under-the-time-concentration curve(AUC). Either for research or for clinical MPA monitoring, a complete AUC is troublesome for the patients(pts). We have developed abbreviated equations in 59 adult(54±16y) pts (29males,43whites) with 171 complete MPA-AUC0-12h, under TAC/EC-MPS using 59 curves measured at mean of 31±4days after transplant, to develop the equations, and the remaining 112 performed at a mean of 109±59d for validation. We also compared our results with 5 other equations(4 with EMIT) available in the literature, comparing estimated AUC(eAUC) with measured AUC(mAUC), bias and 10%/30% accuracy. MPA was measured by UPLC MS-MS. EMIT data was transformed using Emit=1.012HPLC+0.244. The eAUCs that measure MPA up to 6hours, had an acceptable low bias with more results in the 10-30% range than those up to 4h. A highly adequate eAUC is obtained with 8h of blood collection. This analysis offers blood sampling alternatives depending on the precision needed.
|Emit (MPA)||mAUC= 56±36 [micro]g*hr/mL|
|Sanchez Ther Drug Monit, 2012||11.15+0.68xC1+0.45xC1.5+0.57xC2+8.16xC4||57±35||NS||+1±19||74||29|
|Yao Ther Drug Monit, 2015||10.44+0.7xC1+1.22xC2+1.75xC4+4.36xC6||55±29||0.026||-2.5±14||79||40|
|Sommerer Br J Clin Pharmacol, 2010||11.5+0.99xC0+1.56xC1+0.74xC2+0.87xC3+2.09xC4||49±25||0.000||-7±16||78||29|
|Huang Int J Clin Pharmacol Ther, 2016||22.13+1.7xC0.5+0.61xC1.5+0.78xC2+1.83xC4||52±21||0.025||-3±19||67||23|
|(UPLC MS-MS) (MPA)||mAUC = 53±34 [micro]g*hr/mL||eAUC||p||Bias||30%||10%|
|HC –FMUSP8h||0,081+0,661xC0+0,564xC1.5+0,768xC2+1,600xC3+1,560xC4+2,421xC6 +3,590xC8||53±34||NS||0±14||96||56|
|Li Am J Nephrol, 2013||-3.63+8.35xC4+17.04xC7+13.74xC12||121±94||0.000||69±68||11||4|
CITATION INFORMATION: David-Neto E, Triboni A, Ramos F, Agena F, Romano P, Freitas G. A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:David-Neto E, Triboni A, Ramos F, Agena F, Romano P, Freitas G. A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/a-critical-analysis-of-equations-for-mpa-exposure-in-patients-under-ec-mps-and-tacrolimus/. Accessed May 22, 2019.
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