2017 American Transplant Congress
Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.
Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…2017 American Transplant Congress
Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…2017 American Transplant Congress
Preservation Solution Affects the Immunological Milieu in Lung Transplantation and Alters the Inflammatory Balance.
Background: The pro-/ anti-inflammatory balance in lung transplantation is shaped by the pulmonary immune compartments, i.e. the T and NK cell repertoire. At present, it…2017 American Transplant Congress
Neuropeptide PACAP Prevents Hepatocyte Damage by Promoting Yes-Associated Protein (YAP) in Mouse Liver Ischemia/Reperfusion Injury.
Background: Yes-associated protein (YAP), a regulator of cellular anti-oxidation and regeneration, drives cell proliferation and promotes survival. We have previously demonstrated that neuropeptide pituitary adenylate…2017 American Transplant Congress
The Polymer Pro-Drug APP-103 Mitigates I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model.
Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…2017 American Transplant Congress
PPAR-γ Agonist Attenuates Hepatic Ischemia-Reperfusion Injury in a Mouse Model by Regulating Kupffer Cell Polarization.
PPAR-γ agonists have shown protective effect on ischemia-reperfusion injury (IRI) in cerebral and renal tissue. The effects of PPAR-γ on hepatic IRI is unclear. We…2017 American Transplant Congress
Mitochondrial Dysfunction Is a Common Feature of Injury in Donor Kidneys After Brain and Circulatory Death.
The pro-coagulatory and pro-inflammatory environment in donors after brain death (DBD) and warm ischemia in donors after circulatory death (DCD) can cause injury to target…2017 American Transplant Congress
Proteins in Preservation Fluid Predict Delayed Graft Function of Kidneys from Donors After Circulatory Death.
Background and objectivesKidney transplantation is the preferred treatment for end-stage kidney disease, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive value…2017 American Transplant Congress
ERK and HIF1 Play a Major Role in Hypothermic Protection Against Renal Ischemia-Reperfusion Injury.
Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…2017 American Transplant Congress
Autotransplantation of the Left Lung for the Treatment of Recurrent Life Threatening Pulmonary Hemorrhage Related to Pulmonary Vascular Malformation: A Unique Chance to Study Ischemia/Reperfusion Injury.
Background: Ischemia reperfusion injury (IRI) remains a major clinical problem in lung transplantation. Here, we report the investigation of IRI in a 17-year-old patient who…
American Transplant Congress abstracts