ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    The Novel Establishment of Neuroma in Continuity Animal Model Based on Buccal Nerve in Rats.

    Y.-H. Hsieh,1,2 C.-J. Wen,1,3 C.-H. Lin,1,2,3,4 F.-C. Wei,1,2,3 Y.-C. Pei.3,5

    1Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Division of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Department of Physical Medicine & Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Introduction: Peripheral nerve regeneration is a challenging and a rapid growing field. Its application is no longer restricted to trauma reconstruction but also in vascularized…
  • 2017 American Transplant Congress

    Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocytes Viability and Albumin Secretion.

    E. Montanari,1 J. Pimenta,1 H.-J. Schuurman,1 J. Meier,1 R. Meyer,1 A. Balaphas,1 J. Sidibé,2 A. Thomas,2 S. Passemard,3 S. Gerber-Lemaire,3 C. Gonelle-Gispert,1 L. Buhler.1

    1Department of Surgery, University of Geneva, Geneva, Switzerland; 2University Centre of Legal Medicine, Universities of Lausanne and Geneva, Geneva and Lausanne, Switzerland; 3Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Aim: Acute liver failure carries a very high mortality and transplantation of encapsulated pig hepatocytes might temporarily compensate the metabolic functions until the dysfunctional liver…
  • 2017 American Transplant Congress

    Senescence and Uremia Effects in Circulating T Cells Diverge in TREG Population and Cause T Cell Shift to a Memory Profile.

    G. Freitas,1 M. Fernandes,1 F. Agena,1 O. Jabuul,2 V. Coelho,3 F. Lemos,1 F. Ramos,1 A. Triboni,1 E. David-Neto,1 N. Galante.1

    1Renal Transplantation Service, University of Sao Paulo, Sao Paulo, Brazil; 2Department of Geriatrics, University of Sao Paulo, Sao Paulo, Brazil; 3Laboratory of Immunology, InCor, University of Sao Paulo, Sao Paulo, Brazil

    Elderly kidney transplant recipients(EKtx) have higher malignancies and infections rates, but lower acute rejection incidence. Senescence seems to result in shift to memory profile and…
  • 2017 American Transplant Congress

    Technically Successful Miniaturization of Blood Hemofilters for an Artificial Kidney via Bioengineering Techniques.

    R. Forbes,1 C. Kensinger,1 S. Karp,1 J. Groszek,1 A. Buck,2 D. Colvin,2 S. Roy,3 W. Fissell.1

    1Vanderbilt University Medical Center, Nashville; 2Institute of Imagine Science, Vanderbilt University, Nashville; 3University of California San Francisco, San Francisco

    Background: Creating flow channel pathways for an implantable artificial kidney with minimal risk of thrombosis is particularly difficult when miniaturizing into a multilayer bio-hybrid device.…
  • 2017 American Transplant Congress

    Biodistribution of Adipose Derived Regenerative Cells Administered via the Renal Artery in Novel Rat Transplant Model.

    R. Ghita,1,2 R. Lathan,2 D. Hillyard,2 P. Mark,1,2 M. Clancy.1,2

    1Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital Glasgow, Glasgow, United Kingdom; 2Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

    Introduction:A novel rodent model of ischaemia- reperfusion injury (IRI) has shown significant improvement in renal function and histology after administration of adipose derived regenerative cells…
  • 2017 American Transplant Congress

    The Effect of Semimature Dendritic Cell on Transplantation Tolerance of Hepatocytes Differentiated from Mouse Embryonic Stem Cells.

    A. Hu, C. Zhang, W. Liao, X. Zhu, X. He.

    The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Objective Research of semimature dendritic cell(smDCs) inducing transplantation toleranceof hepatocytes differentiated from mouse embryonic stem cells (ESCs) and its mechanismtions.Methods Inducing 129 mouse ESCs labelled…
  • 2017 American Transplant Congress

    Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.

    Y. Goh,1 S. Ho,2 L. Raman,1 V. Anantharaman,3 T. Goh,3 S. Koay,2 H. Tiong.1

    1Urology, National University Hospital, Singapore, Singapore; 2Laboratory Medicine, National University Hospital, Singapore, Singapore; 3Nephrology, National University Hospital, Singapore, Singapore

    IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
  • 2017 American Transplant Congress

    High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8+ Effector T Cells.

    A. Perez-Gutierrez, D. Metes, Y. Ono, A. Thomson, M. Ezzelarab.

    Surgery, University of Pittsburgh, Pittsburgh, PA

    BackgroundThe transcription factors Eomesodermin (Eomes) and T-bet are thought to play critical roles in CD8+ effector memory T cell development. However, the role of Eomes…
  • 2017 American Transplant Congress

    Transcriptome Analysis of CD4-Lymphocyte Specifically Deleted of IKKbeta or NEMO in an Experimental Model of Rapid Progressive Glomerulonephritis (RPGN).

    F. Thaiss,1 J. Huang,2 M. Chen,1 H. Paust,1 G. Zahner,1 M. Alawi,2 R. Geffers,3 L. Guo.1

    1Nephrology, Univ. Hospital UKE, Hamburg, Germany; 2Bioinformatics, Univ. Hospital UKE, Hamburg, Germany; 3Genomics, Helmholtz Center Infection, Braunschweig, Germany

    RPGN is T-cell mediated and can recur after kidney transplantation. T-cell receptor stimulation leads to intracellular signaling events ultimately causing activation of transcription factors such…
  • 2017 American Transplant Congress

    Novel Biomarkers for Segregating Lung Transplant Rejection Phenotypes.

    J. Yang,1 B. Vanaudenaerde,2 T. Sigdel,1 J. Liberto,1 S. Verlden,2 M. Sarwal.1

    1Department of Surgery, University of California, San Francisco, San Francisco, CA; 2Department of Pneumology, University of Leuven, Leuven, Flemish Brabant, Belgium

    We sought to investigate biomarkers in BAL fluid and tissue for segregating BOS and RAS chronic rejection phenotypes in lung allografts. We had previously identified…
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