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Outcomes of Simultaneous Pancreas and Kidney Transplantation Based on Donor Resuscitation

F. Messner1, J. W. Etra2, Y. Yu3, K. Jackson2, A. B. Massie2, G. Brandacher2, S. Schneeberger4, C. Margreiter4, D. L. Segev2

1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, 4Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria

Meeting: 2020 American Transplant Congress

Abstract number: 402

Keywords: Donors, unrelated, Graft survival, Pancreas transplantation, Pancreatitis

Session Information

Session Name: Pancreas and Islet: All Topics I

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

 Presentation Time: 4:15pm-4:27pm

Location: Virtual

*Purpose: It has been hypothesized that transplanting simultaneous pancreas kidney (SPK) grafts from donors with a history of cardiac arrest and cardiopulmonary resuscitation (CACPR) leads to inferior post-transplant outcomes due to organ hypoperfusion during cardiac arrest and mechanical trauma during resuscitation.

*Methods: Using SRTR national registry data, we identified 13,095 SPK transplants 2000-2018. We compared graft and patient survival between recipients of CACPR vs non-CACPR donors using Cox regression and inverse probability weighting to account for covariate imbalance. For secondary outcome variables weighted logistic regression or the logrank test were used.

*Results: 1-, 5- and 10-year patient (CACPR: 96.4%, 89.9%, 78.9%; non-CACPR: 96.3%, 88.9%, 76.0%; p=0.3), death-censored pancreas graft survival (CACPR: 89.3%, 82.7%, 75.0%; non-CACPR: 89.9%, 82.7%, 76.3%; p=0.7), and death-censored kidney graft survival (CACPR: 97.0%, 89.5%, 78.2%; non-CACPR: 96.9.9%, 88.7%, 80.0%; p=0.4) were comparable between the two groups. Both groups displayed a similar rate of postoperative graft pancreatitis (CACPR: 2.9%, non-CACPR: 2.4%; p=0.4), anastomotic leak (CACPR: 1.6%, non-CACPR: 2.0%; p>0.9), or median length of hospital stay (CACPR: 8 days, non-CACPR: 9 days; p=0.6).

*Conclusions: Our findings suggest that CACPR donors can be used to expand the SPK donor pool without compromising short or long-term outcomes.

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To cite this abstract in AMA style:

Messner F, Etra JW, Yu Y, Jackson K, Massie AB, Brandacher G, Schneeberger S, Margreiter C, Segev DL. Outcomes of Simultaneous Pancreas and Kidney Transplantation Based on Donor Resuscitation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-simultaneous-pancreas-and-kidney-transplantation-based-on-donor-resuscitation/. Accessed May 11, 2025.

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