Outcomes of Living and Deceased Donor Liver Transplant Recipients According to the MELD Score.
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Meeting: 2016 American Transplant Congress
Abstract number: B264
Keywords: Liver transplantation, Living-related liver donors, Outcome
Session Information
Session Name: Poster Session B: Liver: MELD, Allocation and Donor Issues (DCD/ECD)
Session Type: Poster Session
Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background
Living donor liver transplantation (LDLT) has developed as an alternative to decease donor liver transplantation (DDLT) to overcome the critical shortage of deceased organ donations. However, the evidence supporting a LDLT for high MELD score recipient is weak. We compared the outcomes of LDLT and DDLT according to MELD scores.
Methods
The study included 498 adult patients who underwent liver transplantation between 2006 and 2014 at Severance Hospital. Patients with re-transplantation and fulminant liver failure were excluded from the study. Recipients were categorized according to their MELD score into low (MELD score ≤25) and high (MELD score >25) MELD group.
Results
About 76.5% of patients are male and median age is 53. Major origin of liver cirrhosis is Hepatitis B virus and 50% of patients had HCC. There were no significant difference gender, donor gender, age, HBV, HCV, HCC and DM. However, age of donor, CTP score and MELD score in DDLT were significantly higher than LDLT. In both LDLT and DDLT groups, patients with high meld score show significantly lower graft survival than patients with low MELD score. (p =0.019 in LDLT and p=0.009 in DDLT) However, in both high and low meld group, there were no significant difference of survival between LDLT and DDLT. Non-HBV, HCC, High MED are risk factor for graft mortality in overall patients. However, HCV and high MELD are risk factor in patients without HCC.
Conclusion
High MELD score is risk factor for Graft mortality in liver recipients regardless combined HCC. There was no significant difference between LDLT and DDLT, in patients with both high MELD and low MELD. When deceased donor organs are scare, LDLT with donor safety maybe good therapeutic option in patient with high MELD score.
CITATION INFORMATION: Lee J, Lee J, Song S, Lee J, Kwon S.-K, Joo D, Ju M, Choi G, Choi J, Kim S, Kim M. Outcomes of Living and Deceased Donor Liver Transplant Recipients According to the MELD Score. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Lee J, Lee J, Song S, Lee J, Kwon S-K, Joo D, Ju M, Choi G, Choi J, Kim S, Kim M. Outcomes of Living and Deceased Donor Liver Transplant Recipients According to the MELD Score. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-living-and-deceased-donor-liver-transplant-recipients-according-to-the-meld-score-2/. Accessed November 22, 2024.« Back to 2016 American Transplant Congress