Patients with polycystic liver disease (PLD) receive liver transplants at various time points in their disease process. Some patients receive liver transplant alone (L), some simultaneous liver and kidney (SLK), and some liver after previous kidney transplant (LaK) based on disease progression. We analyzed outcomes from the UNOS database over 28-year period. A total of 589 patients received liver transplant during this period. Of these, 565 (95.9%) were adults and 34 (4.1%) were children. Of the 565 adults, 247 (43.7%) received L, 261 (46.2%) SLK and 57 (10.1%) LaK. The patients were divided into 4 equal groups of sequential eras as 1987-1994, 1995-2001, 2002-2008, and 2009-2015. The number of transplants for PLD significantly increased from 60 (10.6%) to 104 (18.4%) to 173 (30.6%) to 228 (40.4%) respectively. 545 (96.9%) received a liver transplant from a cadaveric donor. Patient and graft survival are shown in Figure 1 and Figure 2, respectively. In the first era, patient and graft survival were significantly better in L versus SLK (p = 0.01). For patients who received LaK, patient survival increased over time from the second to the fourth era; however, there was no difference in graft survival (p = 0.05). For SLK transplant, patient survival (p = 0.02) and graft survival (p < 0.01) have significantly increased from the first to the last era. In conclusion, an increasing number of patients with PLD are receiving liver transplants, despite allocation changing based on MELD score in which these patients are disadvantaged. The patients with SLK and LaK have significantly improved survival over the examined period of time; however, no difference in survival is seen between these groups.

CITATION INFORMATION: Desai C., Shurney J., Serrano Rodriguez P., Barritt A., Gerber D., Gruessner A. Outcomes of Liver Transplant in Sequential Eras in Patients with Polycystic Liver Disease at Various Stages of Disease Am J Transplant. 2017;17 (suppl 3).

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