ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Outcomes of Intra-Operative Steroid Induction in Liver Transplant Recipients

A. Poparad-Stezar, A. Jantz, T. Larson, B. Summers, N. Sulejmani

Henry Ford Hospital, Detroit, MI

Meeting: 2020 American Transplant Congress

Abstract number: B-136

Keywords: Immunosuppression, Induction therapy

Session Information

Session Name: Poster Session B: Liver: Immunosuppression and Rejection

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Evidence supporting the use of antibody induction (AI) immunosuppression (IS) (antithymocyteglobulin (rATG) and basiliximab (BAS)) for acute rejection (AR) prophylaxis in liver transplant is controversial, and evidence for its use is not as conclusive as it is in other organs. The purpose of this study is to evaluate outcomes after induction protocol change from AI to steroids alone.

*Methods: This is a retrospective quasi experimental single-center descriptive study evaluating incidence of biopsy proven acute rejection (BPAR) between patients (pts) who received AI with rATG or BAS compared to those who did not. Primary outcome assessed the incidence of BPAR, and secondary outcomes assessed the incidence of infection, malignancy, and graft versus host disease (GVHD) up to a year post transplant.

*Results: 100 pts were included, 50 in the AI group (AIG) (74% rATG, 26% BAS) and 50 in the methylprednisolone induction group (MIG), with baseline characteristics shown in Table1. 98 pts received triple maintenance IS of tacrolimus (FK), mycophenolate derivatives, and prednisone within 7 days of transplant; levels/doses similar at day 30, 180, and 360 (Table1). In the AIG, 10 (20%) pts experienced ≥1 BPAR: 9 acute cellular rejection (ACR) and 1 antibody mediated rejection (AMR). In the MIG, 19(38%) pts experienced ≥1 BPAR: 24 ACR and 1 AMR. Median time to rejection was 135 days (85-185) in AIG vs. 103 days (58-161) in the MIG. Pts in the MIG, received an average of 2350mg ±1289 of prednisone equivalents vs. 1835mg ± 921 in the AIG, and had higher incidence of infections, with no change in other negative outcomes.

*Conclusions: Use of steroids alone resulted in more BPAR, shorter time to rejection, and higher rates of infections compared to antibody induction.

 border=

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Poparad-Stezar A, Jantz A, Larson T, Summers B, Sulejmani N. Outcomes of Intra-Operative Steroid Induction in Liver Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-intra-operative-steroid-induction-in-liver-transplant-recipients/. Accessed June 1, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences