ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Normothermic Machine Perfusion (NMP) Improves Access to Transplantation for Late Liver Re-Transplant Candidates

D. Sneiders1, H. Lembach1, A. Hann1, A. Nutu1, J. Hodson1, J. Isaac1, R. Taylor2, M. Armstrong1, T. Perera1, H. Hermien1

1Queen Elizabeth Hospital, Birmingham, United Kingdom, 2NHS Blood and Transplant, bristol, United Kingdom

Meeting: 2022 American Transplant Congress

Abstract number: 518

Keywords: Allocation, Liver grafts, Machine preservation, Retransplantation

Topic: Clinical Science » Liver » 51 - Liver: Retransplantation and Other Complications

Session Information

Session Name: Retransplantation and Other Complications

Session Type: Rapid Fire Oral Abstract

Date: Tuesday, June 7, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 5:40pm-5:50pm

Location: Hynes Room 313

*Purpose: Late liver re-transplantation (LLrT) is a complex surgical procedure. Candidates for LLrT spend longer on the waitlist than primary transplant candidates due to selectivity in accepting organ offers. A service design using NMP was implemented in October 2018 at a single centre to facilitate increased organ utilisation of marginal organs for high-risk recipients. The aim of this study was to assess if this intervention improved access to transplantation.

*Methods: Adult patients electively listed between 2015 and 2020 for LLrT were identified from the national transplant authority database. Transplant rates prior to (period 1) and after (period 2) local implementation of the NMP service design (October 2018) were compared at the study centre and compared to the collective data from other UK centres. A cause-specific Cox regression model was used, with the period modelled as a time-dependent covariate, and the period*centre interaction being the primary factor of interest. The model was corrected for UKELD, age, indication, and blood type. Post-transplant graft survival was assessed with univariable cox regression.

*Results: A total of 144 and 338 LLrT candidates were listed in the study and control centres respectively. At the study centre, the likelihood of transplantation within one year of listing increased from 56% to 68%, whilst a reduction in the LLrT rate was observed at other centres (Figure). Multivariable analysis, showed improved transplant access at the study centre in period 2 (period*centre interaction: HR: 1.83, 95%CI: 1.15-2.9, p=0.01). Post-transplant graft survival was not affected by the intervention (HR: 1.06, 95%CI: 0.41-2.69, p=0.903).

*Conclusions: Implementation of the NMP service design significantly improved access to transplantation for LLrT candidates, without compromising graft survival. While organ utilisation benefit for NMP has been demonstrated before, this is a first study showing a direct patient benefit of NMP for patients with long expected waiting times.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Sneiders D, Lembach H, Hann A, Nutu A, Hodson J, Isaac J, Taylor R, Armstrong M, Perera T, Hermien H. Normothermic Machine Perfusion (NMP) Improves Access to Transplantation for Late Liver Re-Transplant Candidates [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/normothermic-machine-perfusion-nmp-improves-access-to-transplantation-for-late-liver-re-transplant-candidates/. Accessed May 30, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences