Purpose: HIV and HCV are two immune dysregulatory processes that may exacerbate the risk of nonmelanoma skin cancer (NMSC) in organ transplant recipients (OTR), a cohort that exhibits significantly increased risk at baseline due to iatrogenic immunosuppression. Our aim is to elucidate whether OTR with HIV or HCV constitute a unique cohort that demands specialized risk stratification and dermatologic management.

Methods: A retrospective chart review was performed with 427 OTR seen in a 5-year span between 11/1/2011 and 11/1/2016.

Results: Seventy OTR were diagnosed with either HCV or HIV (Table 1). The mean age was 61 years, time of immunosuppression was 7 years, and time from transplant to initial dermatologic visit was 76 days. Two patients were coinfected for both viruses. Nine patients (13%) were diagnosed with NMSC, all of whom were White. Statistical analysis did not reveal significant differences between the HIV/HCV (+) infected White patients vs. non-infected White patients (N=47) for the type or anatomical location of the skin cancer lesions, sun exposure, and time until diagnosis of first lesion. One patient received a heart transplant, 33 received a kidney, 25 received a liver, and 11 received multiorgan transplants.

Conclusions: Our data continues to show the White OTR population to be at risk for NMSC while receiving long-term immunosuppression. Our analysis does not indicate HIV or HCV, two pro-inflammatory viruses, to have an effect on the severity, intensity, or incidence of NMSC.

CITATION INFORMATION: Nadhan K, Usedom E, Shipman S, Doyle A, Malat G, Buchanan E, Chung C. Nonmelanoma Skin Cancer Rates Are Not Affected by Chronic HIV(+) or HCV(+) Infection in Organ Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).

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