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Myosteatosis and its Impact on Graft- and Patient Survival in Adult Recipients of Deceased Donor Liver Transplantation

Z. Czigany, W. Kramp, G. van der Kroft, P. Strnad, M. Zimmermann, W. Liu, G. Wiltberger, U. Neumann, G. Lurje

University Hospital RWTH Aachen, Aachen, Germany

Meeting: 2020 American Transplant Congress

Abstract number: A-165

Keywords: Allocation, Liver transplantation, Morbidity, Surgical complications

Session Information

Session Name: Poster Session A: Liver: Recipient Selection

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Recently our group demonstrated the role of myosteatosis in inferior perioperative outcomes (Czigany et al. Am J Transplant 2019) in recipients of orthotopic liver transplantation (OLT). Here we aimed to investigate the effects of BC on long-term graft- and patient survival following OLT.

*Methods: The data of 225 consecutive OLT recipients were analyzed (05/2010-01/2018). Computed tomography-based lumbar skeletal muscle index-SMI, and mean skeletal muscle radiation attenuation-SM-RA were calculated using a segmentation tool (3DSlicer). Patients with sarcopenia (low SMI), and myosteatosis (low SM-RA) were identified using predefined cutoff values.

*Results: The cutoff values of myosteatosis resulted in a good stratification of patients into low- and high-risk groups in terms of survival. The overall graft- and patient survival rates were significantly lower in myosteatotic patients compared to the subgroup of patients with higher SM-RA values (p=0.011, p=0.001, respectively). Sarcopenia alone was not associated with significant differences in graft- and patient survival rates (p=0.273, p=0.278, respectively). Dividing the patient cohort into quartiles, based on the values of SMI and SM-RA, resulted in significant differences between the SM-RA quartiles in terms of patient survival but not of graft survival (p=0.011). Accordingly, myosteatosis was identified as an independent predictor of inferior patient survival in our cohort (Hazard ratio: 2.260, Confidence interval: 1.177-4.340, p=0.014).

*Conclusions: Our study identifies preoperative myosteatosis as an important factor of inferior graft- and patient survival in liver transplant recipients. These findings underline the clinical significance of preoperative body composition assessment in potential OLT recipients.

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To cite this abstract in AMA style:

Czigany Z, Kramp W, Kroft Gvander, Strnad P, Zimmermann M, Liu W, Wiltberger G, Neumann U, Lurje G. Myosteatosis and its Impact on Graft- and Patient Survival in Adult Recipients of Deceased Donor Liver Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/myosteatosis-and-its-impact-on-graft-and-patient-survival-in-adult-recipients-of-deceased-donor-liver-transplantation/. Accessed May 9, 2025.

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