Introduction: The benefits of live kidney donor transplantation for recipients are well documented. Nevertheless, donor safety and quality of life (QOL) is of paramount importance at all time. Live kidney donation has been proven to be a safe procedure with a very low mortality rate. However, data on QOL remains scarce. This study aimed to identify factors associated with changes in QOL after live kidney donation.
Methods: Data on health-related QOL was prospectively collected from 501 live donors. The Short Form-36, that includes a physical (PCS) and mental component summary score (MCS), was administered pre-operatively and 1, 3, 6 and 12 months after operation. On both scores 50 resembles the score of the healthy Dutch population. The influence of demographic and perioperative factors on the PCS and MCS with linear, quadratic and logarithmic time interaction effects were analyzed with SPSS mixed modelling.
Results: The average PCS and MCS score at baseline was 57.2 (4.8) and 52.9 (6.7) respectively. The average score on the PCS and MCS at month 12 was 54.8 (6.5) and 55.4 (7.5) respectively. Graft loss resulted in a 4.1 point increase on the PCS at month 6 (p=0.002). An increase of 10 kg/m2 in BMI resulted in a 2.2 point decrease on the PCS at month 12 (p=0.015). The MCS at one year was 2.2 higher compared to baseline (p<0.001). Death of the recipient resulted in a decrease on the MCS at month 1 (-2.9), 3 (-1.8) and 6 (-0.6). A 10 year increase in age resulted in 0.7 point reduction on the PCS and a 0.6 reduction on the MCS. Scores on the PCS and MCS at month 12 were higher than the healthy Dutch population. At month 12 male donors had a lower score on the PCS (decrease 0.6, p=0.34) and overall a higher score on the MCS (increase 1.5, p=0.007) compared to women.
Discussion: This is the largest, prospective study assessing QOL in a multivariate fashion with time interactions. Factors associated with a change in health-related QOL were BMI, gender, age and recipient and graft survival. Scores on both the PCS and MCS were excellent, when compared to the healthy Dutch population. Expectations towards a decreased postoperative QOL are unjustified and should pose no barrier to live kidney donation.
To cite this abstract in AMA style:Klop K, IJzermans J, Janki S, Busschbach Jvan, Weimar W, Timman R, Kok N. Multivariate Analysis of Health-Related Quality of Life after Live Kidney Donation, A [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/multivariate-analysis-of-health-related-quality-of-life-after-live-kidney-donation-a/. Accessed October 21, 2020.
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