Living donor liver transplantation (LDLT) is the established treatment for the patients with end stage liver disease. Model for End-stage Liver Disease (MELD) score is widely accepted to predict the mortality on the waiting list for the deceased donor liver transplantation. However, whether MELD score is applicable to predict the outcome of LDLT or not is not clarified yet.
Patients and Methods
We retrospectively analyzed all 223 adult recipients who underwent LDLT at our institute between January 2006 and April 2011 excluding patients with fulminant hepatitis and re-transplantation.
We calculated MELD score based on the lab data on admission. All patients were stratified by every 5 MELD score and divided into 7 groups. First, overall patient survivals as well as graft survivals in all patients and those in patients without HCC (n=138) were analyzed respectively. Second, overall patient survivals of each MELD group were analyzed. Third, we compared survival of the patients with MELD<15 and patients with MELD≥15, since MELD 15 is considered as the borderline whether deceased donor LT recipients obtain survival benefit or not. Finally,we compared the median MELD score between surviving patients and deceased patients.
Median MELD score was 17 for all patients and 19 for non-HCC patients. Among each MELD score groups, there was no significant difference on GRWR as well as the ratio of the ABO incompatible transplantation. For all patients, one year and 3 year patient/graft survivals were 80.6/80.1% and 76.2/75.8% respectively. For non- HCC patients, one year and 3 year patient/graft survivals were 78.9/78.1% and 76.7/75.9% respectively. Patient survivals of each MELD group were not significantly different among 7 MELD groups.
Overall survival rates did not differ significantly between patients with MELD <15 and those with MELD ≥15. There was no statistical difference of the median MELD score between surviving patients and deceased patients.
In our experience, MELD score did not affect outcome after LDLT.
To cite this abstract in AMA style:Tomiyama K, Kaido T, Ogura Y, Hata K, Yoshizawa A, Uemoto S. MELD Score Does Not Predict Outcome of Living Donor Liver Transplantation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/meld-score-does-not-predict-outcome-of-living-donor-liver-transplantation/. Accessed April 6, 2020.
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