Measured Glomerular Filtration Rate of the Remaining Kidney Divided by Its Volume Prior to Donation Is a Predictor of the Long-Term Gain of Function in Living Kidney Donors.
1AP-HP, Georges Pompidou European Hospital, Physiology department, Paris Descartes University, and INSERM, Unit 1151, Paris, France
2AP-HP, Hôpital Necker-Enfants Malades, Renal Transplantation Department, Paris Descartes University, Paris, France
3AP-HP, Hôpital Necker-Enfants Malades, Radiology Department, and Paris Descartes University, Paris, France
4University of Otago, Biostastistic department, Otago, New Zealand
5AP-HP, Georges Pompidou European Hospital , Nuclear Medicine department, Paris Descartes University, and INSERM, Unit 1151, Paris, France
6AP-HP, Georges Pompidou European Hospital , Nuclear Medicine department, Paris Descartes University, and INSERM, Unit 1151, Paris, France
7Toulouse University Hospital, CHU Rangueil, Department of Radiology, Paul Sabatier University, Toulouse, France
8Toulouse University Hospital, CHU Rangueil, Department of Nephrology and Organ Transplantation, Paul Sabatier University, INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France.
Meeting: 2016 American Transplant Congress
Abstract number: C151
Keywords: Donation
Session Information
Date: Monday, June 13, 2016
Session Name: Poster Session C: Kidney Donor Evaluation and Donor Nephrectomy
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Predictors of long-term renal function in living kidney donors are a matter of debate. To describe the predictors of remaining kidney functional gain, we conducted a prospective monocentric study of 63 living kidney donors who had 51Cr-EDTA-measured glomerular filtration rate (mGFR), split renal function by scintigraphy and for volume of the remaining kidney measured by renal CT-scan prior to donationand mGFR at a mean of 5.7±0.5 years after donation. We hypothesized that mGFR of the remaining kidney divided by the volume of this kidney (mGFR/vol) would reflect the density of functional nephrons and would be, consequently, inversely associated with functional gain. The mean mGFR was 97.6±13.0 before donation and was 63.8±9.4 ml/min/1.73 m2 at 5 years. Functional gain averaged 16.2±7.2 ml/min/1.73m2 (+35.3±16.7%). Multivariate analysis showed that age, BMI, and mGFR/vol at donation were negatively correlated with functional gain and had strong predictive power (R squared=0.409) of 5-year functional gain. We confirmed the predictive value of the initial mGFR/vol in an external validation cohort of 39 living donors. In conclusion, for a given age and BMI, living kidney donors will experience a lower 5-year functional gain when they have a greater mGFR/vol at donation.
CITATION INFORMATION: Courbebaisse M, Gaillard F, Le Nestour A, Correas J.-M, Slimani-Thevenet H, Leon C, Eladari D, Timsit M.-O, Otal P, Friedlander G, Houillier P, Kamar N, Legendre C. Measured Glomerular Filtration Rate of the Remaining Kidney Divided by Its Volume Prior to Donation Is a Predictor of the Long-Term Gain of Function in Living Kidney Donors. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Courbebaisse M, Gaillard F, Nestour ALe, Correas J-M, Slimani-Thevenet H, Leon C, Eladari D, Timsit M-O, Otal P, Friedlander G, Houillier P, Kamar N, Legendre C. Measured Glomerular Filtration Rate of the Remaining Kidney Divided by Its Volume Prior to Donation Is a Predictor of the Long-Term Gain of Function in Living Kidney Donors. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/measured-glomerular-filtration-rate-of-the-remaining-kidney-divided-by-its-volume-prior-to-donation-is-a-predictor-of-the-long-term-gain-of-function-in-living-kidney-donors/. Accessed January 17, 2021.« Back to 2016 American Transplant Congress