Date: Monday, June 13, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Predictors of long-term renal function in living kidney donors are a matter of debate. To describe the predictors of remaining kidney functional gain, we conducted a prospective monocentric study of 63 living kidney donors who had 51Cr-EDTA-measured glomerular filtration rate (mGFR), split renal function by scintigraphy and for volume of the remaining kidney measured by renal CT-scan prior to donationand mGFR at a mean of 5.7±0.5 years after donation. We hypothesized that mGFR of the remaining kidney divided by the volume of this kidney (mGFR/vol) would reflect the density of functional nephrons and would be, consequently, inversely associated with functional gain. The mean mGFR was 97.6±13.0 before donation and was 63.8±9.4 ml/min/1.73 m2 at 5 years. Functional gain averaged 16.2±7.2 ml/min/1.73m2 (+35.3±16.7%). Multivariate analysis showed that age, BMI, and mGFR/vol at donation were negatively correlated with functional gain and had strong predictive power (R squared=0.409) of 5-year functional gain. We confirmed the predictive value of the initial mGFR/vol in an external validation cohort of 39 living donors. In conclusion, for a given age and BMI, living kidney donors will experience a lower 5-year functional gain when they have a greater mGFR/vol at donation.
CITATION INFORMATION: Courbebaisse M, Gaillard F, Le Nestour A, Correas J.-M, Slimani-Thevenet H, Leon C, Eladari D, Timsit M.-O, Otal P, Friedlander G, Houillier P, Kamar N, Legendre C. Measured Glomerular Filtration Rate of the Remaining Kidney Divided by Its Volume Prior to Donation Is a Predictor of the Long-Term Gain of Function in Living Kidney Donors. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Courbebaisse M, Gaillard F, Nestour ALe, Correas J-M, Slimani-Thevenet H, Leon C, Eladari D, Timsit M-O, Otal P, Friedlander G, Houillier P, Kamar N, Legendre C. Measured Glomerular Filtration Rate of the Remaining Kidney Divided by Its Volume Prior to Donation Is a Predictor of the Long-Term Gain of Function in Living Kidney Donors. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/measured-glomerular-filtration-rate-of-the-remaining-kidney-divided-by-its-volume-prior-to-donation-is-a-predictor-of-the-long-term-gain-of-function-in-living-kidney-donors/. Accessed November 17, 2019.
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