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Lung Transplantation For Covid-19: An International Registry

M. G. Ison1, R. Giris2, O. Dias3, R. Vos4, J. Magnusson5, T. Zangeneh6, E. D. Lease7, S. Aslam8, M. Weder9

1Northwestern University Comprehensive Transplant Center, Chicago, IL, 2Spectrum Health, Grand Rapids, MI, 3Einstein Hospital, Buenos Aires, Argentina, 4UZ Leuven, Leuven, Belgium, 5Sahlgrenska Transplant Centre, Stockholm, Sweden, 6University of Arizona, Tucscon, AZ, 7University of Washington, Seattle, WA, 8University of California San Diego, San Diego, CA, 9University of Virginia, Charlottesville, VA

Meeting: 2022 American Transplant Congress

Abstract number: 9077

Keywords: COVID-19, Infection, Lung transplantation, Outcome

Topic: Clinical Science » Lung » 64 - Lung: All Topics

Session Information

Session Name: Lung Transplantation

Session Type: Poster Abstract

Date: Monday, June 6, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: SARS-CoV-2 can result in a range of infections from asymptomatic disease to progressive COVID-19 and death. In some patients with COVID-19 Lung Disease (C19LD), lung transplantation (LTx) may be lifesaving. Up to 10% of LTx in the US is currently for patients with C19LD. Understanding the characteristics and outcomes of these patients is critical.

*Methods: A open-access electronic registry was established to collect de-identified data from pts who have undergone LTx for C19LD from centers globally. The study was IRB approved at Northwestern with a wavier for consent (no PHI is collected sites could submit data about pre-Tx, peri-Tx and post-Tx course). Follow-up for 1-yr post-LTx was collected.

*Results: To date, 23 patients with complete day 30 post-LTx data have been entered into the registry. Patient demographics and pre-Tx status are shown in Table 1. 3 patients required oxygen prior to COVID-19 infection. All sites required neg PCR tests prior to listing (22 (95.7%) require 2 neg PCRs). LTx occurred 150 days post-infection and none developed COVID-19 in the first 30 days. Post-Tx ICU LOS averaged 18.6 days with total post-tx hospitalization of 36.3 days (See Table 2). Most LTx experienced infectious and non-infectious morbidity. Most (47.8%) required an additional 36.8 days of rehab. 1 patient died within 30 days due to sepsis.

*Conclusions: The contribution of cases to this international registry is ongoing. While outcomes of LTx for C19LD are generally good, patients experience prolonged post-transplant hospitalization, rehabilitation and significant morbidity.

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To cite this abstract in AMA style:

Ison MG, Giris R, Dias O, Vos R, Magnusson J, Zangeneh T, Lease ED, Aslam S, Weder M. Lung Transplantation For Covid-19: An International Registry [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/lung-transplantation-for-covid-19-an-international-registry/. Accessed May 9, 2025.

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