Long Wait Time Regions for Liver Transplantation for HCC Have a Higher Cumulative Incidence of Death.
Abdominal Transplantation, University of Southern California, Los Angeles, CA
Meeting: 2017 American Transplant Congress
Abstract number: 23
Keywords: Malignancy, Outcome
Session Information
Session Name: Concurrent Session: Clinical Science: Liver - Hepatocellular Carcinoma
Session Type: Concurrent Session
Date: Sunday, April 30, 2017
Session Time: 2:30pm-4:00pm
Presentation Time: 3:18pm-3:30pm
Location: E451b
Purpose: To determine the effect of regional variability in wait time
on survival of patients with hepatocellular carcinoma(HCC) listed for deceased donor liver transplantation(DDLT).
Methods: Patients age>18 with HCC exception points in the OPTN database from 2/27/2002-9/15/2015. Outcomes were calculated and compared between UNOS regions.
Results: 17,023 HCC patients were identified. Median wait time varied by region. One-year transplant rate(region 1,5,9<2,4,7<6,8<3,10,11,p<0.05) and 1-year post-DDLT survival(range:86-92%,p<0.001) varied significantly by region. Cumulative incidence(CI) of post-listing 1-year mortality was significantly higher in long wait time regions 5, 7, 9.[table 1]
Conclusion:
Transplant rate and 1-year post-DDLT survival varies by region. The CI of death is higher in long wait time regions.
| Region | Wait-Time to DDLT
(Median±IQR)(Days) |
1-year CI Death(%)(95% CI) | 1-year Transplant
Rate(%)(95% CI) |
1-year
post-DDLT Survival (%) |
| 1 | 242(119-429) | 1.9(1.0-3.2) | 65.5(60.6-68.1) | 89 |
| 2 | 133(56-288) | 2.0(1.4-2.7) | 79.7(77.7-81.4) | 89 |
| 3 | 53(22-114) | 0.8(0.5-1.2) | 94.1(93-95) | 90 |
| 4 | 152(53-321) | 1.3(0.9-2.0) | 77.1(75-79) | 92 |
| 5 | 274.5(151-482) | 3.3(2.6-4.0) | 58.9(56.9-60.9) | 92 |
| 6 | 97(29-218) | 0.5(0.2-1.5) | 86.6(83.4-89.2) | 92 |
| 7 | 177(88-326.5) | 2.4(1.7-3.4) | 76.3(73.9-78.6) | 89 |
| 8 | 120(43-235) | 1.1(0.6-1.9) | 84.1(81.7-86.2) | 92 |
| 9 | 205(100.5-392) | 3.4(2.4-4.7) | 68.3(65.3-71.2) | 86 |
| 10 | 53(18-110) | 0.7(0.3-1.4) | 92(90.3-93.5) | 90 |
| 11 | 64(27-137) | 0.8(0.4-1.4) | 89.9(88.1-91.4) | 90 |
CITATION INFORMATION: Hogen R, Dinorcia J, Lo M, Nguyen B, Genyk Y, Sher L, Dhanireddy K. Long Wait Time Regions for Liver Transplantation for HCC Have a Higher Cumulative Incidence of Death. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Hogen R, Dinorcia J, Lo M, Nguyen B, Genyk Y, Sher L, Dhanireddy K. Long Wait Time Regions for Liver Transplantation for HCC Have a Higher Cumulative Incidence of Death. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/long-wait-time-regions-for-liver-transplantation-for-hcc-have-a-higher-cumulative-incidence-of-death/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress