Long-Term Outcomes of Elderly Living Donors: A Nationwide Population-Based Study
1-The Catholic University of Korea, -Seoul, Korea, Republic of, 2Yonsei University Wonju College of Medicine, Wonju, Korea, Republic of, 3Department of Information & Statistics, Yonsei University, Wonju, Korea, Republic of
Meeting: 2019 American Transplant Congress
Abstract number: B249
Keywords: Age factors, Donation, Kidney transplantation
Session Information
Session Name: Poster Session B: Kidney Living Donor: Long Term Outcomes
Session Type: Poster Session
Date: Sunday, June 2, 2019
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: The organ shortage for kidney transplantation has increased the demand for living kidney donors, and elderly donors (> 60-years-old) have become more common. Long-term studies of living kidney donors have reported low rates of end-stage kidney disease and mortality. However, the long-term consequences of elderly kidney donors are not widely studied. This study was to investigate the long-term outcomes of elderly kidney donors in a nationwide population-based study.
*Methods: A total of 19,732 living kidney donors were recruited from the Korean National Health Insurance Service database between 2003 and 2016, and followed up for death and development of chronic kidney disease (CKD). Cox proportional hazard model was used to estimate the hazard ratio (HR) for mortality and CKD.
*Results: During follow-up, CKD developed in 5,656 living donors. The CKD incidence increased as donors’ age increased; 22.3% in donors aged ≤30 years, 25.7% in donors aged 31-40 years, 28.4% in donors aged 41-50 years, 33.9% in donors aged 51-60 years, and 34.7% in donors aged > 60 years (P < 0.001). The sex-adjusted HR for CKD increased as the donors’ age increased over 30 years (donors aged ≤30 years as reference); donors aged 31-40 years, HR 1.22 (95% confidence interval [CI] 1.11 - 1.34); donors aged 41-50 years, HR 1.41 (95% CI, 1.29 - 1.54); donors aged 51-60, HR 1.75 (95% CI, 1.60 - 1.91); and donors aged >60 years, HR 1.77 (95% CI, 1.58 – 2.00).During follow-up, death occurred in 635 donors. The all-cause mortality increased as the donors’ age increased; 1.4% in donors aged ≤30 years, 1.5% in donors aged 31-40 years, 2.4% in donors aged 41-50 years, 4.6% in donors aged 51-60 years, and 11.0% in donors aged >60 years (P < 0.001). The sex-adjusted HR for mortality increased as the donors’ age increased over 40 years (donors aged ≤30 years as reference); donors aged 31-40 years, HR 1.18 (95% CI 0.81 - 1.73); donors aged 41-50 years, HR 2.24 (95% CI, 1.60 - 3.16); donors aged 51-60, HR 4.92 (95% CI, 3.56 - 1.6.81); and donors aged >60 years, HR 13.01 (95% CI, 9.31 – 18.17).
*Conclusions: The risk of CKD and mortality increased with donors’ age. Therefore, potential elderly donors should be thoroughly evaluated, and carefully followed up after donation.
To cite this abstract in AMA style:
Yoon H, Kim Y, Shin S, Ahn J, Yang C, Chung B. Long-Term Outcomes of Elderly Living Donors: A Nationwide Population-Based Study [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/long-term-outcomes-of-elderly-living-donors-a-nationwide-population-based-study/. Accessed May 11, 2025.« Back to 2019 American Transplant Congress