Background and Aims: Model for End-Stage Liver Disease (MELD) score is universally used to prioritize patients on the liver transplant (LT) waiting list. There has been conflicting evidence on the use of living donor liver transplantation (LDLT) in patients with high MELD scores. We reported a single-center retrospective data comparing survival between LDLT and deceased donor liver transplantation (DDLT) for patients with MELD score 25. Methods: Between 2001 and 2015, 603 LT were performed at out institution, of which 308 were LDLT and 298 were DDLT. Of those, 178 patients had MELD score >25 (116 DDLT and 62 LDLT). A retrospective analysis was made on patients with high MELD score evaluating age, gender, history of diabetes, renal impairment (using estimated GFR), hospital stay, ICU stay, MELD score at the time of LT and outcome.

Results: Univariate analysis using non-parametric Mann-Whitney test was performed. The joint effect on the survival rate using the potential risk factors was estimated using Cox regression.

. The estimated one, three, and five years survival probabilities are given in

. Age, BMI, renal impairment, MELD score at the time of LT correlated with survival with P value <0.05. The survival between 2 groups was similar

Conclusions: LDLT has similar outcome to DDLT in patients with high MELD score >25, older age, high BMI, renal impairment and higher MELD has worse outcome in both groups.

CITATION INFORMATION: Al Sebayel M, Abaalkhail F, Shoukri M, Albahili H, Alabbad S, AlHamoudi W, Albeshbeshy H, Elsiesy H. Living Donor Liver Transplant Has Similar Outcome to Deceased Donor Liver Transplant for MELD > 25. Am J Transplant. 2016;16 (suppl 3).

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