Background: The incidence of end-stage renal disease (ESRD) following liver transplant (LT) has increased. The actual benefit of kidney transplantation (KT) is not completely understood in LT recipients with ESRD. Methods: We analyzed Scientific Registry of Transplant Recipients data for all KT candidates with prior LT from 1998 to 2014, the benefits of KT relative to remaining on dialysis were compared by multivariate Cox proportional hazard regression analysis. Results: The number of these KT candidates with prior LT has tripled from 98 in 1998 to 323 in 2015.

LT recipients with ESRD remaining on dialysis have 2.5 times increase in the risk of liver graft failure and 3.6 times increase in the risk of patient death compared with these patients receiving KT.

The adjusted liver graft and patient survival rate after donors from donation after cardiac death (DCD) or expanded criteria donors (ECD) kidney transplantation were significantly higher than patients remaining on dialysis in LT recipients with ESRD. Conclusion: The number of referrals to the KT with prior LT is increasing at a rapid rate. Remaining on dialysis in LT recipients with ESRD has profound increased risks of liver graft failure and patient death in comparison to receiving a KT. LT recipients with ESRD can benefit from ECD and DCD kidney transplantation.

CITATION INFORMATION: Ju W., Tang Y., Zhao Q., Jing L., Huang S., Zhu Z., Ji F., Zhang Z., He X., Chen G., Guo Z., Wang D. Liver Transplant Recipients with End-Stage Renal Disease Largely Benefit from Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

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