ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Kidney Donor Profile Index and Recipient BMI Are Potent Predictors of Six Month Deceased Donor eGFR as Opposed to EPTS.

A. Agarwal, W. Ally, D. Maluf, S. Pelletier, K. Brayman.

University of Virginia Health System, Charlottesville, VA.

Meeting: 2016 American Transplant Congress

Abstract number: B189

Keywords: Donors, Glomerular filtration rate (GFR), Kidney transplantation, non-heart-beating

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Kidney Transplantation: KDPI, HCV/Matching, Donor Age

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • The Relationship Between Kidney Donor Profile Index and Six Month eGFR in Deceased Donor Recipients.
  • Recipient Age and KDPI Are Potent Predictors of Early Acute Rejection in the Modern Era of Deceased Donor Kidney Transplantation.

Background: Kidney Donor Profile Index (KDPI) has been shown to be predictive of both short and long term graft survival and is used by transplant centers as the screening tool for donor quality. However, there are limited prospective reports on its predictive ability for short term renal function vs. recipient factors assessed by EPTS. We performed this analysis to explore the relationship between KDPI and eGFR to better understand its use in deceased donor kidney allocation.

Methods: All adult deceased donor kidney transplant recipient with at least 6 month graft survival from a single center institution between 2013 and 2015 were analyzed. eGFR was determined based on the MDRD at 6 months post-transplant. KDPI was calculated per UNOS criteria. Deceased donor and recipient pre and post-transplant parameters were analyzed by a multivariate linear regression to determine their impact on eGFR.

Results: 124 deceased donor recipients were identified with at least 6 month graft function with a mean follow up of 1.5±0.9 years. This analysis focused on adult donors; 3 pediatric en-bloc kidney recipients were excluded. The mean KDPI of these donors was 52±26 (range: 5-100) with mean eGFR of 57±20 ml/min/1.72m2. KDPI and recipient BMI were the most important factors influencing 6 month eGFR. The drop in eGFR associated with increasing BMI was twice that of KDPI. Each 10 unit increase in KDPI resulted in an estimated drop in eGFR of 3.2 ml/min/1.72m2. There were trends for known factors such as delayed graft function and cold ischemia time. Interestingly, highly sensitized patients who qualified for regional/national sharing may be predictive of an improved eGFR suggesting high quality organs are being allocated to this patient population. Recipient intrinsic factors as assessed by both EPTS and its individual components were non-relevant. Recipient demographics such as gender, race, or HLA-matching were also non-contributory.

Covariates Beta Std Error p-value

KDPI

-0.32 0.06 4.87e-07
BMI -0.67 0.29 0.02
Cold time -0.44 0.26 0.096
DGF -5.75 3.43 0.095
cPRA>98% 10.54 7.19 0.15
EPTS -0.009 0.06 0.87

Conclusions: KDPI and recipient BMI are independent predictors which significantly impact short term graft function. Though EPTS may correlate with graft survival, it has minimal utility in predicting eGFR. Therefore, KDPI should be considered when determining optimal organ utilization.

CITATION INFORMATION: Agarwal A, Ally W, Maluf D, Pelletier S, Brayman K. Kidney Donor Profile Index and Recipient BMI Are Potent Predictors of Six Month Deceased Donor eGFR as Opposed to EPTS. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Agarwal A, Ally W, Maluf D, Pelletier S, Brayman K. Kidney Donor Profile Index and Recipient BMI Are Potent Predictors of Six Month Deceased Donor eGFR as Opposed to EPTS. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/kidney-donor-profile-index-and-recipient-bmi-are-potent-predictors-of-six-month-deceased-donor-egfr-as-opposed-to-epts/. Accessed March 6, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Role of Mitochondria, Metabolism and Inflammation: Pathways Influencing Short Term Outcomes Post-Renal Transplantation
    • Factors Influencing Creatinine Rise Following Donor Nephrectomy

    Visit Our Partner Sites

    American Transplant Congress (ATC)

    Visit the official site for the American Transplant Congress »

    American Journal of Transplantation

    The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

    American Society of Transplantation (AST)

    An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

    American Society of Transplant Surgeons (ASTS)

    The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

    Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

    Privacy Policy

    loading Cancel
    Post was not sent - check your email addresses!
    Email check failed, please try again
    Sorry, your blog cannot share posts by email.
    This site uses cookies: Find out more.