Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure?
1Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Canada
2Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
3Division of Nephrology and the Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, Canada
4Division of Nephrology and the Kidney Transplant Program, St. Michael's Hospital, Toronto, Canada.
Meeting: 2016 American Transplant Congress
Abstract number: A58
Keywords: Cadaveric organs, Graft function, Kidney/pancreas transplantation, Outcome
Session Information
Session Name: Poster Session A: Clinical Pancreas Transplantation and All Islet Cell Transplantation Topics
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: Delayed graft function (DGF) in kidney transplant recipients is associated with adverse short and long-term outcomes. However, the impact of DGF of the kidney on pancreas graft survival in recipients of simultaneous pancreas-kidney (SPK) transplant recipients is unclear and has not been studied in a large cohort of SPK transplant recipients.
Methods: A retrospective cohort study was conducted using the Scientific Registry of Transplant Recipients (SRTR) including all adult simultaneous pancreas-kidney (SPK) transplant recipients from 1 Jan 2000 to 31 Dec 2014. Multi-organ transplant recipients, re-transplants (i.e., prior kidney or pancreas transplant recipients) and patients with kidney primary non-function were excluded. DGF was defined as the need for dialysis in the first week after transplantation. The risk of pancreas graft failure in those with vs. without DGF was modeled in multivariable Cox proportional hazards models.
Results: There were 11,345 SPK transplant recipients included in the study, of which 906 experienced DGF. There were 2,142 pancreas graft failures. DGF of the kidney was associated with a 69% increase in the hazard ratio (HR) for pancreas graft failure over follow-up (crude HR 1.69 [95% CI: 1.47, 1.93], p<0.001). After adjustment for recipient, donor, and transplant-related confounders, DGF of the kidney continued to be associated with a significantly elevated risk of pancreas graft failure (adjusted HR 1.42 [95% CI: 1.22, 1.66], p<0.001).
Conclusions: The results of this study show that DGF of the kidney is associated with an increased risk of pancreas graft failure in a large cohort of SPK transplant recipients. Further study is needed to better understand the mechanism underlying the association of DGF with pancreas graft survival and to identify potentially modifiable risk factors.
CITATION INFORMATION: Singh S, Kim S. Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure? Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Singh S, Kim1 S. Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure? [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/is-delayed-graft-function-in-simultaneous-kidney-pancreas-transplant-recipients-associated-with-an-increased-risk-of-pancreas-graft-failure/. Accessed May 10, 2025.« Back to 2016 American Transplant Congress