ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Increasing Proportion of High-Risk Cytomegalovirus (CMV) Donor Positive/recipient Negative (D+R-) Serostatus in Solid Organ Transplant Recipients (SOTRs)

H. Imlay1, M. M. Wagener2, N. Singh2, A. P. Limaye3

1University of Utah, Salt Lake City, UT, 2University of Pittsburgh, Pittsburgh, PA, 3University of Washington, Seattle, WA

Meeting: 2022 American Transplant Congress

Abstract number: 965

Keywords: Cytomeglovirus, High-risk, Organ Selection/Allocation

Topic: Clinical Science » Infection Disease » 24 - All Infections (Excluding Kidney & Viral Hepatitis)

Session Information

Session Name: All Infections (Excluding Kidney & Viral Hepatitis) II

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: CMV D+R- serostatus is independently associated with worse long-term graft and patient survival across many organ transplant types despite current prevention and treatment strategies. Thus, allocation policies (serosorting) to reduce the proportion of CMV D+R- SOTR are being considered. The objectives of this study were to characterize trends in CMV D+R- serostatus among adult organ transplants (SOTs) performed in the United States and to project the proportion of D+R- SOTs in the future.

*Methods: Donor and recipient CMV serostatus and demographic factors previously associated with CMV seropositivity were obtained from the Scientific Registry of Transplant Recipients (SRTR) from 1/1/2000-12/31/2020 for persons ≥18 years undergoing a first SOT. Differences in proportion of D+R- SOTR over time were assessed using chi square for trend. Linear models using the last 10 years were used to model future D+R- status.

*Results: A total of 525,852 SOTs were performed during the study period; 207,510 between 2000-2009 and 318,342 between 2010-2020. The average proportion of CMV D+R- SOTs was stable among kidney recipients and substantively increased among liver, heart, and lung recipients between 2000-2009 and 2010-2020: 17.6% to 17.9% in kidney (p=0.009), 19.2% to 21.5% (p<0.001) in liver, 22.0 to 25.1% in heart (p<0.001), and 23.4% to 26.6% in lung (p<0.001). The increased proportion of CMV D+R- SOTs over time was due primarily to a disproportionate increase in R- status (34% to 36%, p<0.001) without a corresponding increase in D+ donors (60.8% to 60.1%, p<0.001). The projected proportion of CMV D+R- SOTs by 2040 is estimated to be 19.1% in kidney (95% CI 18.5-19.6), 26.3% in liver (95% CI 25.1-27.6), 30.3% in heart (95% CI 28.8-31.9), and 32.1% in lung (95% CI 30.3-33.9) SOTRs.

*Conclusions: There was a significant increase in the proportion of CMV D+R- SOTs across all organs from 2000 to 2020 and there is a projected continued increase over the next 20 years if current trends continue. These changes should inform serosorting-based allocation strategies and prioritize approaches to mitigate the negative impact of CMV D+R- on SOTR outcomes.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Imlay H, Wagener MM, Singh N, Limaye AP. Increasing Proportion of High-Risk Cytomegalovirus (CMV) Donor Positive/recipient Negative (D+R-) Serostatus in Solid Organ Transplant Recipients (SOTRs) [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/increasing-proportion-of-high-risk-cytomegalovirus-cmv-donor-positive-recipient-negative-dr-serostatus-in-solid-organ-transplant-recipients-sotrs/. Accessed May 30, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences