Increased Post-Operative Ventilation Time in Lung Transplant Recipients with Left Ventricular Diastolic Dysfunction
1Indiana University School of Medicine, Indianapolis, IN, 2IU Health, Indianapolis, IN, 3New York Presbyterian Brooklyn Methodist Hospital, New York, NY
Meeting: 2020 American Transplant Congress
Abstract number: C-316
Keywords: Length of stay, Post-operative complications, Prognosis, Survival
Session Information
Session Name: Poster Session C: Lung: All Topics
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: Left ventricular diastolic dysfunction has been shown to be associated with increased morbidity in bilateral lung transplant recipients with pulmonary artery hypertension. It has also been associated with an increased incidence of primary graft dysfunction. This paper sought to determine if left ventricular diastolic dysfunction prior to transplant should be considered a risk factor for worse long-term prognosis in lung transplant recipients.
*Methods: This study retrospectively reviews the medical records of 240 lung transplant patients at a single center from 2014 to 2018. Left ventricular diastolic dysfunction was diagnosed by echocardiogram taken prior to transplant. Outcomes included total length of hospital stay, time spent on ventilator post operatively, and patient survival.
*Results: There were 92 patients with left ventricular diastolic dysfunction prior to transplant (38%). Patients with left ventricular diastolic dysfunction had a higher median age (p<0.001) and higher median body mass index (p<0.01). Patients with idiopathic pulmonary fibrosis were more likely to have left ventricular diastolic dysfunction (p<0.001). Patient survival and length of hospital stay did not differ for patients who had left ventricular diastolic dysfunction prior to transplant compared to those who did not. However, patients with left ventricular diastolic dysfunction did spend more time on the ventilator compared to the control group (p<0.05).
*Conclusions: In this cohort, lung transplant recipients who had left ventricular diastolic dysfunction were more likely to be older and have a higher body mass index compared to those who did not. Additionally, they spent more time on the ventilator compared to patients with normal left ventricular diastolic dysfunction. Patient survival was similar between the two groups. These results suggest that left ventricular diastolic dysfunction may be associated with a more difficult initial hospital course but do not suggest a worse long-term prognosis in lung transplant recipients.
To cite this abstract in AMA style:
Klipsch E, Rachwan R, KutKut I, Roe D, Hage C, Hathaway T, Mangus RS. Increased Post-Operative Ventilation Time in Lung Transplant Recipients with Left Ventricular Diastolic Dysfunction [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/increased-post-operative-ventilation-time-in-lung-transplant-recipients-with-left-ventricular-diastolic-dysfunction/. Accessed June 6, 2025.« Back to 2020 American Transplant Congress