ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Incidental Hepatocellular Carcinoma in Explanted Livers: An Assessment After LIRADS Introduction.

S. Garcia Aroz,1 D. Ludwig,2 K. Fowler,2 N. Vachharajani,1 M. Xu,1 Y. Lin,1 M. Doyle,1 W. Chapman.1

1Surgery, Washington University, St. Louis, MO
2Radiology, Washington University, St. Louis, MO

Meeting: 2017 American Transplant Congress

Abstract number: A71

Keywords: Hepatocellular carcinoma, Liver transplantation, Radiologic assessment

Session Information

Date: Saturday, April 29, 2017

Session Name: Poster Session A: Clinical Science: Liver - Hepatocellular Carcinoma and Cholangiocarcinoma Malignancies

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Hall D1

Related Abstracts
  • Characteristics and Outcomes of Patients With Incidental Hepatocellular Carcinoma Detected in the Explanted Liver Following Transplant
  • Predictors of Ultrasound Failure to Detect Hepatocellular Carcinoma in Cirrhotic Livers.

Background: Despite new technologies and improvements in imaging diagnosis, incidental and misdiagnosed hepatocellular carcinomas (HCC) are entities that remain present and problematic in liver transplantation.

Methods: From January 1, 2006 through December 31, 2015, 921 liver transplants were performed at our center; 345 of them with diagnosis of HCC. We retrospectively identified all cases of incidental and misdiagnosed HCC in explant livers of patients without previous diagnosis of HCC (n=576). Pre-transplant imaging tests were reviewed by a single radiologist to determine the concordance between lesions observed on MRI, using LIRADSv2013 classification, and the final pathology report of each lesion.

Results: 45 patients (7.8%) presented with an incidental or misdiagnosed HCC. 20 patients presented an incidental HCC not observed on MRIs pre-transplantation (3.5% incidental HCC rate), and 25 presented misdiagnosed tumors; lesions described on MRI/CT pre-transplantation but not diagnosed as HCC (4.3% of misdiagnosed rate). Reviewing retrospectively imaging tests (MRI/CT) performed pre-transplantation, we found that 37 lesions were identified prior to surgery in these patients. 27 lesions (73%) were LR3; indeterminate for HCC. 3 lesions (8.1%) were LR4; probably HCC. 4 lesions (10.8%) were LR4/5, and 3 lesions (8.1%) were LR5; definitely HCC. 8 of these 49 patients showed elevated AFP levels (median 21.3 ng/mL, range 12.9-71 ng/mL) before transplantation; 4 of them corresponded to LR3 lesions on MRIs, 1 corresponded to LR4, and 3 were incidental HCC.

Conclusion: Incidental or misdiagnosed malignancy is a rare but reported finding at the time of liver transplantation and have been related to worse outcomes and higher rates of recurrence after transplantation. New imaging algorithms, such as LI-RADS or the OPTN classification system focus primarily on specificity rather than sensitivity and hence lesions that do not meet criteria may still represent HCC.

CITATION INFORMATION: Garcia Aroz S, Ludwig D, Fowler K, Vachharajani N, Xu M, Lin Y, Doyle M, Chapman W. Incidental Hepatocellular Carcinoma in Explanted Livers: An Assessment After LIRADS Introduction. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Aroz SGarcia, Ludwig D, Fowler K, Vachharajani N, Xu M, Lin Y, Doyle M, Chapman W. Incidental Hepatocellular Carcinoma in Explanted Livers: An Assessment After LIRADS Introduction. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/incidental-hepatocellular-carcinoma-in-explanted-livers-an-assessment-after-lirads-introduction/. Accessed January 25, 2021.

« Back to 2017 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.