Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury.
1Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, Muenster, Germany
2Department of General and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.
Meeting: 2016 American Transplant Congress
Abstract number: A242
Keywords: Donors, Graft function, Kidney transplantation, marginal
Session Information
Session Name: Poster Session A: Long Term Outcomes in Kidney Transplantation
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Given the gap between patients in need of a kidney transplantation and organs available, transplantation centers increasingly accept lower quality organs, e.g. from donors with acute kidney injury.
To determine the outcome of kidney transplants from deceased donors with acute kidney injury (AKI, defined as ≥ AKIN stage 1), all 109 kidney transplant recipients who received a renal allograft from donors with AKI between August 2004 and July 2014 at our center were compared to their respective consecutively transplanted patients receiving kidneys from donors without AKI. We assessed the frequencies of delayed graft function (DGF, need for dialysis < 1 week post transplantation), graft loss and biopsy proven rejection within the first year after transplantation and compared serum creatinine levels at one year after transplantation.
Recipients from donors with AKI showed higher frequencies of DGF and allograft loss within the first year after transplantation (36.7% vs. 16.5%, p=0.001 and 6.4% vs. 0.9%, p=0.005, Fisher's exact test), and had higher one-year serum creatinine levels (1.92±1.0 mg/dl vs. 1.49±0.6 mg/dl, p=0.002, Mann-Whitney U test). Prevalence of patients who had one or more acute biopsy proven rejection episodes within the first year after transplantation was similar in both groups (19.3% vs. 15.6%, p=0.39).
In our cohort, both short-term and long-term outcome was worse in patients with kidney allografts from donors with AKI, while other groups report higher rates of DGF in AKI donor recipients, but similar long term outcome. Our data indicates that additional factors impairing long term outcome, e.g. cold ischemia time, should be minimized with particular precaution once kidneys from donors with AKI are considered for transplantation.
CITATION INFORMATION: Schuette-Nuetgen K, Thölking G, Pavenstädt H, Ehlert S, Suwelack B, Palmes D, Bahde R, Reuter S. Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Schuette-Nuetgen K, Thölking G, Pavenstädt H, Ehlert S, Suwelack B, Palmes D, Bahde R, Reuter S. Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/impaired-outcome-of-kidney-transplants-from-donors-with-acute-kidney-injury/. Accessed May 9, 2025.« Back to 2016 American Transplant Congress