Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants
U of MN, Minneapolis.
Meeting: 2018 American Transplant Congress
Abstract number: A205
Keywords: Glomerular filtration rate (GFR), Graft function, Kidney transplantation, Rejection
Session Information
Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Background: In the non-transplant setting, hyperchloremia has been associated with kidney injury. We sought to study the impact of serum chloride (SCl) on transplant outcomes.
Methods: We analyzed 936 living donor kidney transplants (LDKT) between '05-'17. A SCl on the day of transplant was compared to the SCl post-operative day 2 (POD2). The outcomes were 30-day eGFR and cellular rejection (ACR) within 90 days. A multivariate Cox Proportional Hazards model was performed. A multivariate linear regression was used to predict 30-day eGFR based on change in SCl.
Results: The average change in SCl on POD2 was an increase by 1.29 (0.95-1.64). Increasing SCl levels (from day of transplant to POD2) were associated with a decreased risk of 90-day ACR HR 0.92 (0.88-0.95, p<0.01). Additionally, 30-day eGFR increased by 0.45ml/min/1.73m2 (0.13-0.77, p=0.01) for each 1 unit increase in SCl on POD2.
Conclusion: A postoperative SCl increase was not associated with deleterious outcome in LDKT.
Baseline Characteristics
| ↓ SCl (n=363) | ↑ SCl (n=502) | No Change in SCl (n=71) | P Value | |
| Age | 50.8 | 47.2 | 49.1 | <0.01 |
| Male % | 63.4 | 65.3 | 62.0 | 0.76 |
| White % | 90.9 | 87.5 | 91.5 | 0.22 |
| BMI | 26.9 | 26.6 | 27.3 | 0.55 |
| Prior Tx | 14.6 | 15.1 | 9.9 | 0.50 |
| DM % | 35.5 | 31.5 | 28.2 | 0.31 |
| PRA I % | 0.41 | |||
| 0-19 | 83.3 | 86.6 | 85.5 | |
| 20-74 | 14.4 | 10.8 | 14.5 | |
| 75+ | 2.3 | 2.4 | 0 | |
| PRA II % | 0.06 | |||
| 0-19 | 87.0 | 82.6 | 83.8 | |
| 20-74 | 8.9 | 15.2 | 11.8 | |
| 75+ | 4.0 | 2.2 | 4.4 |
CITATION INFORMATION: Vakil V., Keys D., Junghare M., Jackson S., Berglund D., Matas A., Riad S. Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Vakil V, Keys D, Junghare M, Jackson S, Berglund D, Matas A, Riad S. Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-postoperative-serum-chloride-changes-on-graft-function-and-acute-rejection-in-recipients-of-living-kidney-transplants/. Accessed November 21, 2024.« Back to 2018 American Transplant Congress