Impact of New Pancreas Transplant Allocation Policy on Pancreas Transplant Volume and Outcomes: A Single Center Study
LSU, Shreveport, LA.
Meeting: 2018 American Transplant Congress
Abstract number: A369
Keywords: Allocation, Graft function, Kidney/pancreas transplantation, Post-operative complications
Session Information
Session Name: Poster Session A: Pancreas and Islet: All Topics
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
BACKGROUND: A UNOS/OPTN policy approved in 2015 allowed simultaneous pancreas-kidney transplants (SPK) for type-2 diabetic patients. We examined the effect of this policy on volume of SPK as well as outcomes of type-2 diabetic patients receiving SPK at our center.
RESULTS: From Jan 2007 to Nov 2017, we did 78 SPK. Prior to Jan 2015, SPK were performed only for type-1 diabetic patients (N=42) and after 2015, SPK were done for both type-1 (N=26) and type-2 diabetic patients (N=10)-Figure-1. 
All type-2 diabetic patients receiving SPK had C-peptide>2, were on insulin, and had BMI≤30 pre-transplant (Tx). The characteristics of type-1 vs. type-2 diabetic patients with SPK pre- and post-Tx are shown in Table-1.
| TYPE-1 DM WITH SPK (N=68) | TYPE-2 DM WITH SPK (N=10) | P-VALUE | |
| AGE(MEAN±S.D)(yrs) | 41.3±8.3 | 45.1±3.1 | NS |
| MALES(%) | 36(53%) | 8(80%) | NS |
| AFRICAN AMERICAN RACE (%) | 26(38%) | 5(50%) | NS |
| BMI(Mean±S.D) | |||
| -pre-Tx | 26.6±4.7 | 28.6±3.0 | NS |
| -post-Tx (3mo) | 25.1±4.5 | 31.1±2.5 | 0.005 |
| -post-Tx (6mo) | 26.0±4.9 | 31.7±2.0 | 0.009 |
| -post-Tx (1yr) | 27.4±5.5 | 33.1±1.8 | 0.04 |
| C-peptide(Mean±S.D) | |||
| -pre-Tx | 0.3±0.4 | 6.0±4.4 | <0.001 |
| -post-Tx(3mo) | 3.6±2.2 | 7.0±5.5 | 0.09 |
| -post-Tx(6mo) | 2.7±1.1 | 9.3±8.0 | 0.03 |
| -post-Tx(1yr) | 3.4±2.4 | 8.2±8.1 | NS |
| e-GFR(ml/min/m2)(Mean±S.D) | |||
| -post-Tx(1mo) | 66.0±27.7 | 68.1±24.7 | NS |
| – post-Tx(6mo) | 66.7±20.6 | 60.8±18.2 | NS |
| – post-Tx(1yr) | 60.0±22.0 | 49.6±24.2 | NS |
Type 2 diabetic SPK patients gained more wt. post-Tx compared with type-1 patients. All type 2 diabetic SPK patients were alive and had working pancreas and kidney Tx with no insulin use till last f/u.
CONCLUSION: New pancreas Tx allocation policy has helped improve pancreas transplant volume at our center, with 28% of all SPK done in type-2 diabetic patients since Jan 2015 with excellent short-term outcomes.
CITATION INFORMATION: Singh N., Pulisetty A., Aultman D., McMillan R., Zibari G., Shokouh-Amiri H. Impact of New Pancreas Transplant Allocation Policy on Pancreas Transplant Volume and Outcomes: A Single Center Study Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Singh N, Pulisetty A, Aultman D, McMillan R, Zibari G, Shokouh-Amiri H. Impact of New Pancreas Transplant Allocation Policy on Pancreas Transplant Volume and Outcomes: A Single Center Study [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-new-pancreas-transplant-allocation-policy-on-pancreas-transplant-volume-and-outcomes-a-single-center-study/. Accessed November 21, 2024.« Back to 2018 American Transplant Congress