ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Impact of Immunogenicity on Kidney Allograft Survival in Patients Treated with Induction Therapy

R. Michael, B. Mierzejewska, D. Bekbolsynov, J. Ortiz, O. Ekwenna, S. Stepkowski

University of Toledo, Toledo, OH

Meeting: 2020 American Transplant Congress

Abstract number: 105

Keywords: HLA matching, Induction therapy, Kidney transplantation

Session Information

Session Name: Histocompatibility and Immunogenetics

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

 Presentation Time: 3:39pm-3:51pm

Location: Virtual

*Purpose: The induction therapy is currently used in the majority of kidney transplant recipients, regardless of their level of donor/recipient compatibility. We examined whether lower immunogenicity (IM) between donor and recipient improved allograft survivals in groups of recipients treated with three different induction therapies or without induction.

*Methods: We analyzed 30,648 deceased kidney transplants from 2009 to 2011 (SRTR database): 25,528 were with induction, namely 14,675 with anti-thymocyte globulin (equine or rabbit, ATG), 4,139 with anti-CD52 mAb (alemtuzumab, Alem), 6,714 with interleukin-2 receptor inhibitor (basiliximab, IL2-RI), whereas 5,120 remained without any induction. HLA-A/B/DR of donors and recipients were imputed from 2-digit to 4-digit HLAs by HaploStats algorithm. Each donor/recipient pair’s immunogenicity (IM) was then estimated by the Kosmoliaptsis algorithm, namely electrostatic mismatch score (EMS); pairs with IM scores above median (50th percentile) were considered as high EMS IM and below as low EMS IM.

*Results: The 5-year death-censored graft survival for all induction groups combined was better than without induction (p <0.001; Fig. 1A); each of three induction groups (ATG, Alem, IL2-RI) was also superior to no induction (p <0.001; not shown). When no induction group (Fig. 1B), all induction groups combined (Fig. 1C), and each of the induction groups (ATG, Fig. 1D; Alem, Fig. 1E; and IL2-RI, Fig. 1F) were stratified by IM (EMS), there was a significant difference in the survival between low and high EMS groups (p <0.05; except of Alem, p=0.14). High and low IM groups for each induction therapy had the same distribution of HLA-A/B/DR mismatches: i.e. more pairs with 0-3 mismatches and less pairs with 5/6 mismatches in low IM groups vs. less pairs with 0-3 mismatches and more with 5/6 mismatches in high IM groups.

*Conclusions: 1) Independently of the induction protocol low EMS IM donor/recipient pairs display better graft survival than high EMS IM pairs; 2) Selection of low IM donor/recipient pairs by EMS may improve long-term kidney allograft survivals; and 3) 5/6 HLA mismatches have low IM pairs.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Michael R, Mierzejewska B, Bekbolsynov D, Ortiz J, Ekwenna O, Stepkowski S. Impact of Immunogenicity on Kidney Allograft Survival in Patients Treated with Induction Therapy [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-immunogenicity-on-kidney-allograft-survival-in-patients-treated-with-induction-therapy-2/. Accessed May 11, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences