ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Impact of High-Risk EBV Discordance Status on Survival Outcomes in Kidney Transplant Recipients: A Multivariable Analysis

A. Dinesh1, S. Jackson2, T. L. Pruett1, S. Riad3

1Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, 2Biostatistics, Analytics Consulting Services- Solid Organ Transplant, M Health Fairview, Minneapolis, MN, 3Department of Medicine, University of Minnesota, Minneapolis, MN

Meeting: 2021 American Transplant Congress

Abstract number: 165

Keywords: Epstein-Barr virus (EBV), Graft survival, Kidney transplantation, Survival

Topic: Clinical Science » Infectious Disease » Kidney Infectious Non-Polyoma & Non-Viral Hepatitis

Session Information

Session Name: Infections in Kidney Recipients

Session Type: Rapid Fire Oral Abstract

Date: Sunday, June 6, 2021

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:35pm-6:40pm

Location: Virtual

*Purpose: High-risk EBV discordance has been linked to Post-Transplant Lymphoproliferative Disorder (PTLD) after kidney transplantation; however, the impact on recipient and graft survival is under-reported. We sought to examine the survival outcomes by EBV concordance status.

*Methods: We retrospectively reviewed all primary kidney transplant recipients from 2008-2019. At our institution, we use Thymoglobulin (r-ATG) induction with early steroid withdrawal followed by CNI plus MMF maintenance. We grouped the patients according to EBV status into high-risk status recipients (EBV IgG R-/D+) (n=62) and low-risk status recipients (EBV IgG R+/D+, R+/D- or R-/D-) (n=1224). Kaplan-Meier curves were generated for recipient survival, death-censored graft survival, and EBV infection-free survival. We examined the effect of EBV high-risk status on outcomes of interest in a multivariable Cox proportional hazards model adjusted for age, gender, race, BMI, maintenance immunosuppression, and donor type. EBV-free survival was not modeled due to severe proportional hazard violations.

*Results: In univariate analysis, neither patient (log-rank, p=0.466) nor death censored graft survival (log-rank, p=0.349) differed between low and high-risk groups. However, EBV-free survival was significantly lower in the high-risk group (log-rank, p<0.001). In the multivariable model, high-risk EBV status was associated with a 2.3-fold increased risk of mortality compared to low-risk status [HR 2.3, 95% C.I. (1.09, 4.76), p=0.03]. However, EBV status was not a predictor for death-censored graft survival in the adjusted model. The live-donor kidney was associated with 52% improved patient survival and 64% improved graft survival, independent of EBV status.

*Conclusions: In primary kidney transplant recipients receiving r-ATG induction immunosuppression followed by CNI plus MMF maintenance with early steroid withdrawal, the incidence of post-transplant EBV viremia is significantly higher in the (R-/D+) group. As compared to low-risk status recipients, EBV high-risk status recipients had increased mortality.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Dinesh A, Jackson S, Pruett TL, Riad S. Impact of High-Risk EBV Discordance Status on Survival Outcomes in Kidney Transplant Recipients: A Multivariable Analysis [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-high-risk-ebv-discordance-status-on-survival-outcomes-in-kidney-transplant-recipients-a-multivariable-analysis/. Accessed May 9, 2025.

« Back to 2021 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences