ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Impact of Delayed Kidney Graft Function (DGF) after Simultaneous Liver and Kidney Transplantation (SLKT) on Patient Outcomes: Results from the US Multicenter SLKT Consortium

P. Sharma1, Z. Sui1, M. Zhang1, J. Magee1, P. Barman2, K. Walters3, A. Schluger4, R. Wong5, G. Cullaro6, J. Sinha7, J. Jo7, Y. Patel8, S. Biggins9, J. Lai5, L. VanWangner7, E. Verna6

1Michigan Medicine, Ann Arbor, MI, 2UCSD, San Diego, CA, 3UCLA, LA, CA, 4Westchester Medical Center, Westchester, NY, 5UCSF, San Francisco, CA, 6Columbia, New York, NY, 7Northwestern, Chicago, IL, 8Duke, Durham, NC, 9University of Washington, Seattle, WA

Meeting: 2020 American Transplant Congress

Abstract number: C-136

Keywords: Graft function, Kidney/liver transplantation, Outcome

Session Information

Session Name: Poster Session C: Liver - Kidney Issues in Liver Transplantation

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Delayed kidney graft function (DGF) after SLKT transplant may be associated with increased risk of kidney graft loss, morbidity and mortality. We examined the incidence and predictors of DGF after SLKT in a contemporary large multicenter cohort, and determine its impact on length of stay (LOS) of transplant admission.

*Methods: The US Multicenter SLKT consortium consists of candidate, donor and recipient data on all adult (≥18yrs) recipients of SLKT at 6 large centers in 6 different UNOS regions between Feb 2002 to June 2017. DGF was defined as transient use renal replacement therapy (RRT) within 7 days after SLKT transplant. Multivariable logistic regression was used to identify the predictors of DGF and to understand the impact of DGF on patient outcomes including LOS of transplant admission, kidney graft loss defined as recurrent stage 4-5 CKD and patient survival.

*Results: A total of 570 patients were evaluated, with a median age of 58 years (IQR:51-64), 37% female, 76% Caucasian, 33% hepatitis C, 20% NASH, and 23% had alcohol-related liver disease. Median MELD-Na at SLKT was 28 (IQR 23-34). Only 39% were on RRT at SLKT. One hundred thirty-three (23%) developed DGF requiring RRT during the transplant hospitalization, for a median of 13 days (IQR:4-40) and 25 had early kidney graft loss within first year. Black (OR= 0.332;P=0.012) and White race (OR=0.345;P<0.001) compared to others races (Hispanics, Asians and others), pre-LT RRT (OR=3.94;P<0.001), advanced donor age (OR=1.03 per year; P<0.001) and cold ischemia time(CIT) (OR=1.002 per minute; P=0.018) were independently associated with increased odds of DGF, adjusting for recipient age, sex, etiology of liver disease, type of renal failure, pre-LT hypertension, BMI, diabetes, MELD-Na, renal risk index, immunosuppression and induction. Patients with DGF had a longer mean LOS of transplant admission (37.8±34.9 days vs. 23.9±24.1 days; P<.0001), higher rates of post-SLKT recurrent stage 4-5 CKD (32% vs. 17%; P<0.001). However, long-term overall patient survival was in DGF vs. no-DGF group(64% vs. 68%; P=0.3).

*Conclusions: DGF affected one fourth of SLKT recipients, and is significantly associated with prolonged transplant admission LOS and recurrent stage 4-5 CKD including kidney graft loss. Efforts should be taken to minimize DGF in order to improve long-term renal outcomes after SLKT.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Sharma P, Sui Z, Zhang M, Magee J, Barman P, Walters K, Schluger A, Wong R, Cullaro G, Sinha J, Jo J, Patel Y, Biggins S, Lai J, VanWangner L, Verna E. Impact of Delayed Kidney Graft Function (DGF) after Simultaneous Liver and Kidney Transplantation (SLKT) on Patient Outcomes: Results from the US Multicenter SLKT Consortium [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-delayed-kidney-graft-function-dgf-after-simultaneous-liver-and-kidney-transplantation-slkt-on-patient-outcomes-results-from-the-us-multicenter-slkt-consortium/. Accessed June 6, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences