Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Introduction: Smoking is known to result in the decline of renal allograft function and survival of recipients. However, effect of smoking on living kidney donor remains unknown. This study was conducted to evaluate the impact of cigarette smoking on renal function of kidney donors.
Methods: Among 1056 donors who underwent donor nephrectomy between March 2006 and September 2016, subjects who completed the 6-month follow-up protocol after donation were enrolled in this study. The association of smoking status and postoperative renal function was evaluated. In former and current smokers, the relation between pack-years smoking history and renal function was also evaluated.
Results: Among 612 donors, 68.1% had never smoked, 8% were former smokers and 23.9% were current smokers. Never smoked donors were older than former and current smokers (42.3 ± 11.8, 41.9 ± 11.1, and 38.3 ± 10.9 years, respectively; p < 0.001). There was no difference in preoperative renal function between groups, however 6-month estimated GFR (eGFR) was lower in former and current smokers than never smoked donors (64.6 ± 13.8, 64.7 ± 12.3, and 67.8 ± 13.1 mL/min/1.73 m2, respectively; p=0.023). Smoking history was associated with development of chronic kidney disease (CKD), defined as eGFR < 60mL/min/1.73m2, 6 month postoperatively (p=0.007). In former and current smokers, pack-years smoking history was negatively associated with preoperative and postoperative eGFR (r = -0.305 and -0.435; p<0.001), and also correlated with percent of eGFR decrease (r = 0.248, p<0.001). Especially in former smokers, longer than 12 pack-years smoking history was strongly associated with development of CKD (OR=7.5, p=0.003).
Conclusion: Donors with smoking history require close observation because there is a greater possibility of development of CKD after kidney donation even if they already quit smoking. A detailed pack-years smoking history should be routinely obtained before kidney donation and smoking cessation strategies should be implemented.
CITATION INFORMATION: Yoon Y., Lee H., Na J., Huh K., Kim M., Kim S., Kim Y., Han W. Impact of Cigarette Smoking on Living Kidney Donor Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Yoon Y, Lee H, Na J, Huh K, Kim M, Kim S, Kim Y, Han W. Impact of Cigarette Smoking on Living Kidney Donor [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-cigarette-smoking-on-living-kidney-donor/. Accessed April 21, 2019.
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