Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
C Salabe1, S Zschiedrich2, P Pisarski1, BM Jänigen1
1 Department of General and Digestive Surgery, Section of Transplant Surgery, University Medical Centre Freiburg, Freiburg, Germany
2 Renal Division, Department of Medicine, University Medical Centre Freiburg, Freiburg, Germany
Background: In 2004 AB0-incompatible kidney transplantation (AB0i KTx) was introduced in Germany. Meanwhile, it is an established procedure to expand the living donor pool, comprising more than 20 % of all living donor kidney transplantations in our country. Up to September 2015 more than 100 AB0i KTx were performed at the Transplant Center Freiburg and long-term graft and patient survival are equal to AB0-compatible recipients (AB0c KTx). In regard to surgical complications, especially the formation of postoperative lymphoceles, only very scarce data exists.
Methods: Between April 2004 and September 2015 100 consecutive AB0i and 118 AB0c KTx, receiving an immunsosuppressive protocol including basiliximab, tacrolimus, mycophenol acid and corticosteroids. Additionally, all AB0i recipients received rituximab 4 weeks prior to scheduled transplantation and immunoadsorption. We retrospectively analyzed the data in regard to postoperative lymphocele formation.
Results: In AB0i KTx recipients the incidence of lymphocele formation was 23.0 % and thereby significantly higher in contrast to the AB0c KTx recipients with 9.3 % (p < 0.01). A main risk factor was more frequent preoperative immunoadsorption (IA) sessions (AB0i KTX without lymphocele (n=77): 5.84 ± 3.58; AB0i KTx with lymphocele (n=23): 7.96 ± 5.18; p=0.03). Especially recipients receiving 8 and more IA sessions show a trend in developing lymphocele (≤ 7 IA sessions: 18.1 % and ≥ 8 IA sessions: 35.8 %; p=0.07).
Conclusion: AB0i KTx is a safe technique and long-term results are not inferior to AB0c KTx. However, lymphoceles occur more commonly after AB0i KTx and can endanger the renal transplant. This leads to the need of more frequent interventional or surgical procedures in ABOi KTx.
CITATION INFORMATION: Salabe C., Zschiedrich S., Pisarski P., Jänigen B. Impact of AB0-Incompatible Kidney Transplantation on Lymphocele Formation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Salabe C, Zschiedrich S, Pisarski P, Jänigen B. Impact of AB0-Incompatible Kidney Transplantation on Lymphocele Formation [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-ab0-incompatible-kidney-transplantation-on-lymphocele-formation/. Accessed February 23, 2019.
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