ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Iguratimod Reduce Panel Reactive Antibody in High Mismatched Renal Transplant Recipients: A Retrospective Propensity Score-Matched Study

D. Feng, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Meeting: 2021 American Transplant Congress

Abstract number: 914

Keywords: Alloantigens, Kidney transplantation

Topic: Clinical Science » Kidney » Kidney Immunosuppression: Desensitization

Session Information

Session Name: Kidney Immunosuppression: Desensitization

Session Type: Poster Abstract

Session Date & Time: None. Available on demand.

Location: Virtual

*Purpose: To evaluate the clinical efficacy and safety of iguratimod (IGU) for reducing panel reactive antibody (PRA) in high mismatched renal transplant recipients.

*Methods: Eligible recipients found positive PRA with or without IGU administered were enrolled. Propensity score matching (PSM) analysis was conducted to eliminate the difference between the IGU group and the No IGU group. After adjustment, MFI changes of PRA before and after drug treatment between the two groups were assessed. Adverse reactions or side effects were also reviewed.

*Results: 54 recipients were included eventually after 1:1 matching analysis. 340 and 144 PRA sites were detected in the IGU group and the No IGU group, respectively. The proportion of PRA sites with decreased MFI was obviously higher in the IGU group than in the No IGU group. After IGU taken for 9 months, significantly MFI decrease was seen in anti-HLA class I, anti-HLA class II, anti-HLA class I and class II, anti-HLA A, anti-HLA B, anti-HLA Cw, anti-HLA DQ and anti-HLA DR antibody sites (P <0.05), except of anti-HLA DP antibody sites (P >0.05). Decrease of PRA in the IGU group was greater than in the No IGU group in anti-HLA class I, anti-HLA class II, anti-HLA class I and class II, anti-HLA A, anti-HLA DR antibody sites (P <0.05), except in anti-HLA Cw, anti-HLA DP and anti-HLA DQ antibody sites (P >0.05). Adverse reactions or side effects was identical between the two groups (P >0.05).

*Conclusions: IGU can effectively reduce PRA in high mismatched renal transplant recipients and can be applied safely without serious adverse effects.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Feng D, Wang Z, Han Z, Tao J, Ju X, Tan R, Gu M. Iguratimod Reduce Panel Reactive Antibody in High Mismatched Renal Transplant Recipients: A Retrospective Propensity Score-Matched Study [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/iguratimod-reduce-panel-reactive-antibody-in-high-mismatched-renal-transplant-recipients-a-retrospective-propensity-score-matched-study/. Accessed May 8, 2025.

« Back to 2021 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences