Background: Outcomes of hyponatremia during immediate post-lung transplantation are unknown. We aim to identify the incidence of postoperative hyponatremia and its outcomes.

Methods: All lung transplantations at Northwestern Memorial Hospital since the first case performed in July 2014 until the end of August 2015 were reviewed. The severity of hyponatremia was defined as mild, moderate, and severe with serum Na of <135, <130, and <125 mEq/L, respectively.

Results: A total of 19 lung transplant recipients were identified. Mean age was 61.16±1.75 (SEM) years and 68% was female. Mean duration of follow-up was 6.82±1.04 months (0.73-12.73). Serum creatinine at the time of transplantation and at discharge was 0.80±0.04 and 0.9±0.13 mg/dL, respectively. The majority of patients developed postoperative hyponatremia (79%) (Table 1). Eleven patients with postoperative acute kidney injury (AKI) had twice longer length of hospitalization (24.27±3.76 vs. 12.0±2.1 days; p=0.0072) but AKI were not associated with increased postoperative hyponatremia (82% vs. 75%; p=1.000). At the time of transplant, 11% of the patients had hyponatremia but the incidence was up to 42% at the time of discharge (Table 1). Around one-third of the patients had persisent hyponatremia during 1 month follow-up but almost all returned to be normonatremic at the outpatient follow-up visit.

Conclusions: Lung transplant recipients commonly develop hyponatremia during the immediate postoperative period. The incidence of hyponatremia remains high up to 1 month post transplantation and resolves after the mean duration of 6 months. AKI may predict longer length of hospital stay.

CITATION INFORMATION: Tantisattamo E, Chokechanachaisakul A, Traitanon O, Shetty A, Ho B, Friedewald J, Bhorade S, Haynes A, Nieland A, Gallon L. Hyponatremia in Early Post Lung Transplantation Predicts Patient and Hospital Outcomes. Am J Transplant. 2016;16 (suppl 3).

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